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  4. Recombinant Mouse E3 ubiquitin-protein ligase MIB1 (Mib1), partial

Recombinant Mouse E3 ubiquitin-protein ligase MIB1 (Mib1), partial

  • 中文名称：
    小鼠Mib1重组蛋白
  • 货号：
    CSB-YP768867MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mib1重组蛋白
  • 货号：
    CSB-EP768867MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mib1重组蛋白
  • 货号：
    CSB-EP768867MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mib1重组蛋白
  • 货号：
    CSB-BP768867MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mib1重组蛋白
  • 货号：
    CSB-MP768867MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mib1
  • Uniprot No.：
    Q80SY4
  • 别名：
    Mib1; Dip1; Kiaa1323; Mib; E3 ubiquitin-protein ligase MIB1; EC 2.3.2.27; DAPK-interacting protein 1; DIP-1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
  • 基因功能参考文献：
    1. Mib1 is necessary for the Notch activation in adjacent retinal progenitor cell (RPC)The retinal pigment epithelium (RPE) expresses active Notch ligands for adjacent RPC PMID: 28402857
    2. Deletion of Mib1 resulted in an increase in the fraction of pendrin positive intercalated cells in the kidney. PMID: 25594189
    3. Loss of MIB1 and dismantling of the apical secretory apparatus was the earliest quantifiable aberration in zymogenic cells undergoing transition to a precancerous metaplastic state in mouse. PMID: 23478405
    4. These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus. PMID: 23111145
    5. Mib1 is a major component of the signal-sending cells required to provide Notch ligand activity for specifying neurons and glia in the spinal cord PMID: 23223237
    6. In contrast to delta-like 1 (Dll1) protein, delta-like 4 (deltall4) function relies on a combination of factors, including strong Mindbomb1 (Mib1) association, ubiquitination, and internalization and recycling back to the cell surface, to engage Notch1 effectively. PMID: 23162128
    7. Mib1 in dendritic cells is critical for the activation of Notch signaling in CD4(+) T cells PMID: 22558446
    8. Data show that Mind bomb 1 (Mib1) is required for correct proximodistal (P-D) patterning of the developing pancreas and beta-cell formation. PMID: 22529374
    9. show that exogenously expressed Mib1 could partially rescue the phenotypes associated with miR-137 overexpression. PMID: 20506192
    10. mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis. PMID: 16000382
    11. A targeted mutation of Mib1 in mice results in embryonic lethality;MIB1 activity is required for S3 cleavage of the Notch1 receptor. PMID: 16061358
    12. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1 PMID: 17003037
    13. data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable PMID: 18043734
    14. These results suggest that Mib1 is important for intraembryonic hematopoiesis not only in the aortic endothelium but also in the subaortic patches. PMID: 18505817
    15. Myeloproliferative disease development in the Mib1 CKO mice is due to defective Notch activation in the nonhematopoietic cells. PMID: 18818392
    16. Mib1 is the essential E3 ligase in T and marginal zone B cell development, through the regulation of Notch ligands in the thymic and splenic microenvironments. PMID: 18824586

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm. Cell membrane.
  • 组织特异性：
    Detected in all tissues tested. Present in embryo, embryonic stem cells, bladder, skeletal muscle, bladder, uterus, testis, stomach, colon, ileum, trachea, lung, aorta, kidney, spleen, liver and vas deferens (at protein level). Highly expressed in testis.
  • 数据库链接：

    KEGG: mmu:225164

    STRING: 10090.ENSMUSP00000054428

    UniGene: Mm.21500

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