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  4. Recombinant Mouse Down syndrome cell adhesion molecule homolog (Dscam), partial

Recombinant Mouse Down syndrome cell adhesion molecule homolog (Dscam), partial

  • 中文名称：
    小鼠Dscam重组蛋白
  • 货号：
    CSB-YP863658MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dscam重组蛋白
  • 货号：
    CSB-EP863658MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dscam重组蛋白
  • 货号：
    CSB-EP863658MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dscam重组蛋白
  • 货号：
    CSB-BP863658MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dscam重组蛋白
  • 货号：
    CSB-MP863658MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dscam
  • Uniprot No.：
    Q9ERC8
  • 别名：
    Dscam; Down syndrome cell adhesion molecule homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC. In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.
  • 基因功能参考文献：
    1. The diversity resides on the adhesive side, positioning DSCAM as a generalized modulator of cell adhesion during neural development. PMID: 30297418
    2. Results identify DSCAM-cell-adhesion molecule-mediated inhibition as a regulator of circuit-level neuronal plasticity in the adult mice retina. PMID: 29114051
    3. Findings indicate Down syndrome cell adhesion molecule (Dscam) as a permissive signal that promotes the growth and fasciculation of retinal ganglion cell (RGC) axons, controlling the timing of when RGC axons reach their targets. PMID: 28137836
    4. Together, these results demonstrate that different cell types have different dependencies on the PDZ-interacting C-termini of DSCAM and DSCAML1 for function, indicating multiple intracellular molecular mechanisms are involved. PMID: 27637097
    5. work presents the correlation between DSCAM gene overexpression and a dysregulation of the P21-activated kinases pathway. PMID: 26966010
    6. DSCAM mutation induces dystonic hypertonia and a disruption of locomotor gaits. PMID: 26683069
    7. DSCAM mutation reduces or abolishes spinal reflexes in both neonatal isolated spinal cords and adult mice. PMID: 26655819
    8. Our results indicate an important role of DSCAM and DSCAML1 in the development of cortical neural network. PMID: 25451118
    9. DSCAM colocalizes in developmentally dynamic patterns with adhesion and synaptic proteins in the mouse retina. PMID: 25352748
    10. The findings of this study are as follows: (1) DSCAM is sufficient to drive cell death (2) dendrite avoidance defects in the Dscam loss-of-function retina do not reflect a role for DSCAM, and necessary and sufficient to target neurites. PMID: 25855178
    11. A novel splice isoform of Dscam causes defects in lamination of type 2 and type 6 cone bipolar cells in Dscam mutant mice. PMID: 23300735
    12. DSCAM contributes to pyramidal neuron morphogenesis by regulating dendrite arborization and spine formation during cortical circuit development PMID: 23175819
    13. somal clustering and fasciculation observed in the Dscam mutant retina are not unique to Dscam deficiency and are manifested distinctively by different retinal cell types. PMID: 22396220
    14. Data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system. PMID: 21904980
    15. DSCAM is not required for Netrin-induced commissural axon outgrowth and guidance in mice. PMID: 22238077
    16. Deletion of Dscam in specific cell types causes cell-type-autonomous cell body spacing defects, indicating that DSCAM mediates arborization and spacing by acting within given cell types. PMID: 22063212
    17. overexpression of DSCAM in the cerebral cortex might play an important role in the learning and memory defects of amyloid precursor protein transgenic mice. PMID: 21241773
    18. A novel null allele of mouse Dscam survives to adulthood on an inbred C3H background with reduced phenotypic variability. PMID: 20715164
    19. Impairment of the N-methyl-D-aspartate (NMDA)-mediated regulation of DSCAM translation may contribute to alterations in dendritic morphology and/or synaptic plasticity in Down's syndrome. PMID: 20926679
    20. DSCAM plays a critical role in central respiratory regulation. PMID: 20217312
    21. Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain PMID: 11856873
    22. A specific promoter region directs expression of DSCAM in the developing choroid plexus and roof of the fourth ventricle, the floor plate of the fourth ventricle, pons and medulla oblongata, and the eye, limb buds, and dorsal root ganglion PMID: 12435380
    23. mouse DSCAM mediates isoneuronal self-avoidance for arborization and heteroneuronal self-avoidance within specific cell types to prevent fasciculation and to preserve mosaic spacing PMID: 18216855
    24. Dscam proteins function as attractive receptors for Netrin and also act in parallel to Frazzled/DCC. PMID: 18948420
    25. This review summarizes the powerful regulation of the mosaic spacing of neurons in the mammalian retina by DSCAM, but not their synaptic specificity. PMID: 19945385

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell junction, synapse. Cell projection, dendrite. Cell projection, growth cone.
  • 组织特异性：
    Expressed in cortical and cerebellar neurons, in cells of the external and internal granular layer and of the Purkinje cell layer (at protein level). In the retina, expressed in dopaminergic and Nos1-positive amacrine cells and most retinal ganglion cells
  • 数据库链接：

    KEGG: mmu:13508

    STRING: 10090.ENSMUSP00000056040

    UniGene: Mm.102437

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