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  4. Recombinant Mouse Doublesex- and mab-3-related transcription factor 1 (Dmrt1)

Recombinant Mouse Doublesex- and mab-3-related transcription factor 1 (Dmrt1)

  • 中文名称：
    小鼠Dmrt1重组蛋白
  • 货号：
    CSB-YP865605MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dmrt1重组蛋白
  • 货号：
    CSB-EP865605MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dmrt1重组蛋白
  • 货号：
    CSB-EP865605MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dmrt1重组蛋白
  • 货号：
    CSB-BP865605MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dmrt1重组蛋白
  • 货号：
    CSB-MP865605MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dmrt1
  • Uniprot No.：
    Q9QZ59
  • 别名：
    Dmrt1Doublesex- and mab-3-related transcription factor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-374
  • 氨基酸序列
    MPNDDTFGKP STPTEVPHAP GAPPQGKAGG YSKAAGAMAG AAGGSGAGGS GGASGSGPSG LGSGSKKSPR LPKCARCRNH GYASPLKGHK RFCMWRDCQC KKCSLIAERQ RVMAAQVALR RQQAQEEELG ISHPIPLPSA AELLVKRENN ASNPCLMAEN SSSAQPPPAS TPTPAASEGR MVIQDIPAVT SRGHMENTSD LVSDPAYYSS FYQPSLFPYY NNLYNYPQYS MALSAESSSG EVGNSLGGSP VKNSLRSLPA PYVPAQTGNQ WQMKTSESRH PVSSQYRMHS YYGPPSYLGQ SMSQIFTFEE GPSYSEAKAS VFSPPSSQDS GLVSLSSSSP MSNESSKGVL ECESASSEPS SYAVNQVLEE DEDE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis.
  • 基因功能参考文献：
    1. miR-224 overexpression increases the expression of GFRalpha1 and PLZF, accompanied by the down-regulation of DMRT1 in mouse testes. PMID: 27099200
    2. Dmrt1 supports spermatogonial stem cell pool homeostasis. PMID: 27583450
    3. DMRT1 expression in the ovary silenced the female sex-maintenance gene Foxl2 and reprogrammed juvenile and adult granulosa cells into Sertoli-like cells, triggering formation of structures resembling male seminiferous tubules. PMID: 25683803
    4. Enforced expression of Dmrt1 in XX mouse fetal gonads using a Wt1-BAC transgene system is sufficient to drive testicular differentiation and male secondary sex development. PMID: 25725066
    5. spontaneous SSC reprogramming is caused by unstable DNA methylation and that a Dmrt1-Sox2 cascade is critical for regulating pluripotency in SSCs PMID: 24029916
    6. DMRT1 controls pluripotency via transcriptional repression of Esrrb, Nr5a2/Lrh1, and Sox2. PMID: 23473982
    7. sexual fate is surprisingly labile in the testis: loss of the DMRT1 transcription factor in mouse Sertoli cells, even in adults, activates Foxl2 and reprograms Sertoli cells into granulosa cells PMID: 21775990
    8. These results suggest that novel ncRNA gene Dmr might play a negative regulatory role for Dmrt1 in male sexual development. PMID: 20816665
    9. By coordinating spermatogonial development and mitotic amplification with meiosis, DMRT1 allows abundant, continuous production of sperm. PMID: 20951351
    10. Data revealed that DMRT1 is a bifunctional transcriptional regulator, activating some genes and repressing others. PMID: 20616082
    11. Conditional gene targeting indicates that Dmrt1 is required in fetal germ cells but not in Sertoli cells to prevent teratoma formation. PMID: 20007774
    12. Mutants targeting mouse dmrt1 affected knockdown effects of the gene by the RNA interference in both transfected cells and endogenous Sertoli cells PMID: 16720339
    13. Both 5' and 3' flanking sequences control the expression of Dmrt1. PMID: 16825170
    14. These results provide new insight into roles of regulation at level of splicing of the Dmrt1 in governing sex differentiation. PMID: 17141192
    15. Dmrt1 is required in Sertoli cells for their postnatal differentiation, and for germ line maintenance and for meiotic progression. PMID: 17540358
    16. Studying DMRT1 it was found that target gene specificity of the DMRT proteins does not derive exclusively from major differences in DNA binding specificity. PMID: 17605809
    17. mRNA expression profiling was done to identify genes misregulated in the neonatal Dmrt1 mutant testis. PMID: 18391515

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DMRT family
  • 组织特异性：
    Testis-specific. In adult testis, expressed in Sertoli cells in all regions of the seminiferous tubules. Expressed dynamically in premeiotic germ cells (spermatogonia), with high expression only in regions of the seminiferous tubule that are early in the
  • 数据库链接：

    KEGG: mmu:50796

    STRING: 10090.ENSMUSP00000025755

    UniGene: Mm.391208

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