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  4. Recombinant Mouse Dimethyladenosine transferase 1, mitochondrial (Tfb1m)

Recombinant Mouse Dimethyladenosine transferase 1, mitochondrial (Tfb1m)

  • 中文名称：
    小鼠Tfb1m重组蛋白
  • 货号：
    CSB-YP023420MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tfb1m重组蛋白
  • 货号：
    CSB-EP023420MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tfb1m重组蛋白
  • 货号：
    CSB-EP023420MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tfb1m重组蛋白
  • 货号：
    CSB-BP023420MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tfb1m重组蛋白
  • 货号：
    CSB-MP023420MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tfb1m
  • Uniprot No.：
    Q8JZM0
  • 别名：
    Tfb1m; Dimethyladenosine transferase 1; mitochondrial; EC 2.1.1.-; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; mtTFB1; S-adenosylmethionine-6-N'; N'-adenosyl(rRNA) dimethyltransferase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-345
  • 氨基酸序列
    RAV KQLSQNFLLD LRLTDKIVRK AGSLADVYVY EVGPGPGGIT RSILNANVAE LLVVEKDTRF IPGLQMLSDA APGKLRIVHG DVLTYKIEKA FPGNIRRQWE DDPPNVHIIG NLPFSVSTPL IIKWLENISL KDGPFVYGRT KMTLTFQKEV AERLVATTGS KQHSRLSIMA QYLCNVEHLF TIPGKAFVPK PKVDVGVVHL TPLIEPKIKQ PFKLVEKVVQ NAFQFRRKYC HRGLGMLFPE AQRLESTGRL LQLADIDPTL RPTHLSLMHF KSLCDVYRKM CDEDPQLFTY NFREELKQKK SKGQEKDGDP ESCGF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
  • 基因功能参考文献：
    1. Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. PMID: 24916378
    2. Metazoans have two TFBM genes, suggesting that a duplication of the gene has permitted a more flexible regulation of mtDNA. PMID: 12532263
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family, KsgA subfamily
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    KEGG: mmu:224481

    STRING: 10090.ENSMUSP00000035291

    UniGene: Mm.226554

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