Recombinant Mouse Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (Dlat)

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中文名称：

小鼠Dlat重组蛋白
货号：

CSB-EP804374MOa0
规格：

￥2328
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP804374MOa0 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Dlat.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP804374MOa0 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Dlat.
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纯度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Dlat
Uniprot No.：

Q8BMF4
别名：

Dlat; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; mitochondrial; EC 2.3.1.12; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2
种属：

Mus musculus (Mouse)
蛋白长度：

Full Length of Mature Protein
来源：

E.coli
分子量：

62.8 kDa
表达区域：

86-642aa
氨基酸序列

SLPPHQKVPLPSLSPTMQAGTIARWEKKEGEKISEGDLIAEVETDKATVGFESLEECYMAKILVPEGTRDVPVGSIICITVEKPQDIEAFKNYTLDLAAAAAPQAAPAAAPAPAAAPAAPSASAPGSSYPTHMQIVLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGAPLCIIVEKQEDIAAFADYRPTEVTSLKPQAAPPAPPPVAAVPPTPQPVAPTPSAAPAGPKGRVFVSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPSKAAPAAAAAMAPPGPRVAPAPAGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKELNKMLEGKGKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPITMLL
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

N-terminal 6xHis-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

Tris-based buffer，50% glycerol
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

3-7 business days
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
产品描述：

DLAT是线粒体内的一种蛋白质，它是丙酮酸脱氢酶复合物（Pyruvate Dehydrogenase Complex，简称 PDC）的一部分，负责催化乙酰辅酶A的合成。PDC是一种分布于线粒体基质中的多酶复合体，通过催化丙酮酸的氧化脱羧反应生成乙酰辅酶A，有效连接糖酵解和三羧酸循环。在科研上，DLAT的重组蛋白被广泛用于各种研究中。例如，它被用于加速信号传导研究，因为它是细胞内复杂世界的关键组成部分。此外，DLAT的重组蛋白也被用于研究肿瘤免疫逃逸，因为研究发现，丙酮酸脱氢酶复合物E1组分α亚基（PDHE1α）存在丰富的胞质定位，并且在肿瘤免疫逃逸中起着重要的作用。
华美生物提供大肠杆菌表达系统制备的全长DLAT重组蛋白，可帮助您更好地理解细胞内的复杂机制，有望为疾病的治疗提供新的思路和方法。
Datasheet & COA：

Please contact us to get it.

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功能：

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
基因功能参考文献：
1. These data reveal a central role for Dlat in the metabolic program regulated by E4F1 in basal keratinocytes. PMID: 27621431
2. On the basis of our ChIP data and these previous findings, we hypothesize that PDC may modulate STAT5's ability to regulate gene expression by controlling histone or STAT5 acetylation PMID: 28982698
3. breach of tolerance to PDC-E2 is probably the first event in the natural history of primary biliary cirrhosis in genetically susceptible hosts. PMID: 24128311
4. a novel function of pyruvate dehydrogenase complex E2 in the nucleus in up-regulating the transactivating ability of STAT5 PMID: 21397011
亚细胞定位：

Mitochondrion matrix.
蛋白家族：

2-oxoacid dehydrogenase family
数据库链接：

KEGG: mmu:235339

STRING: 10090.ENSMUSP00000034567

UniGene: Mm.285076

Recombinant Mouse Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (Dlat)

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