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  4. Recombinant Mouse Dickkopf-related protein 4 (Dkk4)

Recombinant Mouse Dickkopf-related protein 4 (Dkk4)

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  • 中文名称：
    小鼠Dkk4重组蛋白
  • 货号：
    CSB-EP837727MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Dkk4
  • Uniprot No.：
    Q8VEJ3
  • 别名：
    Dickkopf-4;Dkk-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    35.4 kDa
  • 表达区域：
    19-221aa
  • 氨基酸序列
    LVLDFNNIKSSADVQGAGKGSLCASDRDCSEGKFCLAFHDERSFCATCRRVRRRCQRSAVCCPGTVCVNDVCTAVEDTRPVMDRNTDGQDGAYAEGTTKWPAEENRPQGKPSTKKSQSSKGQEGESCLRTSDCGPGLCCARHFWTKICKPVLREGQVCSRRGHKDTAQAPEIFQRCDCGPGLTCRSQVTSNRQHSRLRVCQRI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Dkk4 Proteins

靶点详情

  • 功能：
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 基因功能参考文献：
    1. the dynamic state of Dkk4 itself and its interaction with Lrp6 modulates Wnt function during Meibomian gland development, with a novel limitation of Dkk4 action by proteolytic cleavage. PMID: 27864382
    2. sweat gland development shows a relay of regulatory steps initiated by Wnt/beta-catenin - itself modulated by Dkk4 - with subsequent participation of Eda and Shh pathways. PMID: 25249463
    3. These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt/beta-catenin signaling, providing new insights into the relationship between Wnt/beta-catenin signaling and Dkk4 in bone formation. PMID: 24105477
    4. It would appear that deregulation of the WNT pathway by overexpression of DKK4 may further impair WNT signaling and lead to Anorectal malformations. PMID: 23108157
    5. Dkk4 affects an auxiliary pathway for Eda-independent development of secondary hair PMID: 20386733
    6. Dkk4 acts in a negative feedback loop to attenuate canonical Wnt signaling and may facilitate a switch to the non-canonical Wnt planar cell polarity pathway that is involved in cell movements during morphogenesis. PMID: 17397822
    7. Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 in embryonic eda(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway. PMID: 18508042

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Dickkopf family
  • 数据库链接：

    KEGG: mmu:234130

    STRING: 10090.ENSMUSP00000033936

    UniGene: Mm.157322

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