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  4. Recombinant Mouse Dead end protein homolog 1 (Dnd1)

Recombinant Mouse Dead end protein homolog 1 (Dnd1)

  • 中文名称：
    小鼠Dnd1重组蛋白
  • 货号：
    CSB-YP757815MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dnd1重组蛋白
  • 货号：
    CSB-EP757815MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dnd1重组蛋白
  • 货号：
    CSB-EP757815MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dnd1重组蛋白
  • 货号：
    CSB-BP757815MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dnd1重组蛋白
  • 货号：
    CSB-MP757815MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dnd1
  • Uniprot No.：
    Q6VY05
  • 别名：
    Dnd1; Rbms4; TerDead end protein homolog 1; RNA-binding motif; single-stranded-interacting protein 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-352
  • 氨基酸序列
    MQSKRECEQW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV GSPPPSGSEV YIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF AYARYSSRRG AQAAIATLHN HQLRPSCQLL VCRSTEKCEL TVDGLPLSLN RRALLLALQP FGPCLQETLL LPSPGSAPSQ IALLKFSTHR AAAMAKKALV EGQSRLCGEQ VAVEWLKPDL KQHFRQQLAG PSLRFLRPDV SQLTQTREKL GSQGARAALQ LLCQRMKLGS PVFLTKCLGT GPAGWHRFWY QVVIPGHPVP FSGLIWVVLA SDWQDGHEVA KDAVSAQLLE ALSEPRTSLW SPGAEAGTMV KQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. Isoform 1 may play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration.
  • 基因功能参考文献：
    1. DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase complex. PMID: 28297718
    2. DND1 interacts with NANOS2 to load unique RNAs into the CCR4-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2, which is essential for its association with target RNAs; DND1 is an essential partner for NANOS2 that leads to the degradation of specific RNAs in male germ cell development PMID: 26589352
    3. Dnd1 heterozygotes, lower oxygen availability was associated with metabolic differences PMID: 26224005
    4. results show that Dnd1 is essential for normal allelic inheritance and that Dnd1Ter has a novel combination of functions that significantly increase risk for both testicular and intestinal cancer PMID: 23773267
    5. DND1 is the first protein known to have an RNA recognition motif directly implicated as a heritable cause of spontaneous tumorigenesis PMID: 15902260
    6. DND1-alpha isoform to be necessary for germ cell viability and its loss in Ter mice results in germ cell depletion, germ cell tumor development and partial embryonic lethality in the 129 strain. PMID: 17291453
    7. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. PMID: 17616517
    8. The role of dead-end in germ-cell tumor development. PMID: 17905939
    9. when Dnd1(Ter/Ter) XX germ cells developed in a testicular environment they gave rise to the same neoplastic clusters as mutant XY germ cells in a testis. PMID: 19389346

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  • 相关疾病：
    Defects in Dnd1 are the cause of the Ter mutation phenotype. Ter mice are characterized by primordial germ cell loss and susceptibility to spontaneous testicular germ cell tumors (TGCT). They are sterile, but viable. Isoform 1 defects may be the cause of tumor development.
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed in testis. Isoform 1 is expressed continuously in post natal (PN) testis although levels are low between PN1 to PN6. Isoform 2 is expressed from PN 20 onwards. Isoform 2 is strongly expressed in meiotic and in post-me
  • 数据库链接：

    KEGG: mmu:213236

    STRING: 10090.ENSMUSP00000054412

    UniGene: Mm.234464

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