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  4. Recombinant Mouse DNA repair protein XRCC2 (Xrcc2)

Recombinant Mouse DNA repair protein XRCC2 (Xrcc2)

  • 中文名称：
    小鼠Xrcc2重组蛋白
  • 货号：
    CSB-YP866622MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Xrcc2重组蛋白
  • 货号：
    CSB-EP866622MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Xrcc2重组蛋白
  • 货号：
    CSB-EP866622MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Xrcc2重组蛋白
  • 货号：
    CSB-BP866622MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Xrcc2重组蛋白
  • 货号：
    CSB-MP866622MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Xrcc2
  • Uniprot No.：
    Q9CX47
  • 别名：
    Xrcc2; DNA repair protein XRCC2; X-ray repair cross-complementing protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-278
  • 氨基酸序列
    MCSDFRRAES GTELLARLEG RSSLKELEPN LFADEDSPVH GDIFEFHGPE GTGKTEMLYH LTARCILPKS EGGLQIEVLF IDTDYHFDML RLVTVLEHRL SQSSEEAMKL CLARLFLAYC SSSMQLLLTL HSLEALLCSR PSLCLLIVDS LSSFYWIDRV SGGESVALQE STLQKCSQLL ERLVTEYRLL LFATTQSLMQ KGSDSADGPS SSKHPCDGDM GYRAYLCKAW QRVVKHRVIF SRDDEAKSSR FSLVSRHLKS NSLKKHSFMV RESGVEFC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
  • 基因功能参考文献：
    1. involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms PMID: 26300006
    2. Data show that XRCC2 and other homologous recombination proteins, including the key recombinase RAD51, co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle. PMID: 21276791
    3. These findings indicate that Xrcc2 haploinsufficiency reduces spontaneous tumor incidence on an Apc(min/+) background but increases the tumorigenic response to radiation. PMID: 20671066
    4. An important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage. PMID: 20189471
    5. Order-of-magnitude higher levels of chromosomal alterations are sustained in primary or immortal Xrcc2(-/-) embryonic fibroblasts. PMID: 14678973
    6. the normal developmental programme is perturbed in Xrcc2-/- embryonic tissues, particularly during neurogenesis and somitogenesis PMID: 17116431
    7. ATP hydrolysis by Rad51 is more important for some homologous recombination functions than it is for other aspects of DNA repair PMID: 17719855
    8. Xrcc2 is important to preserve or restore replication forks during rapid clonal expansion of developing lymphocytes. PMID: 18212067
    9. DNA replication licensing factor MCM2 and DNA mismatch repair (MMR) protein MSH2 were confirmed to be present in co-precipitations with MmXRCC2. PMID: 19658102

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RecA family, RAD51 subfamily
  • 组织特异性：
    Expressed at low level in somatic tissues and at high level in testis.
  • 数据库链接：

    KEGG: mmu:57434

    STRING: 10090.ENSMUSP00000030773

    UniGene: Mm.143767

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