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  4. Recombinant Mouse DNA-binding protein SATB2 (Satb2)

Recombinant Mouse DNA-binding protein SATB2 (Satb2)

  • 中文名称：
    小鼠Satb2重组蛋白
  • 货号：
    CSB-YP837746MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Satb2重组蛋白
  • 货号：
    CSB-EP837746MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Satb2重组蛋白
  • 货号：
    CSB-EP837746MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Satb2重组蛋白
  • 货号：
    CSB-BP837746MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Satb2重组蛋白
  • 货号：
    CSB-MP837746MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Satb2
  • Uniprot No.：
    Q8VI24
  • 别名：
    Satb2; Kiaa1034DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-733
  • 氨基酸序列
    MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA VAKAVGGLMI PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA LLALGYSHSS AAQAQGIIKL GRWNPLPLSY VTDAPDATVA DMLQDVYHVV TLKIQLQSCS KLEDLPAEQW NHATVRNALK ELLKEMNQST LAKECPLSQS MISSIVNSTY YANVSATKCQ EFGRWYKKYK KIKVERVERE NLSDYCVLGQ RPMHLPNMNQ LASLGKTNEQ SPHSQIHHST PIRNQVPALQ PIMSPGLLSP QLSPQLVRQQ IAMAHLINQQ IAVSRLLAHQ HPQAINQQFL NHPPIPRAVK PEPTNSSVEV SPDIYQQVRD ELKRASVSQA VFARVAFNRT QGLLSEILRK EEDPRTASQS LLVNLRAMQN FLNLPEVERD RIYQDERERS MNPNVSMVSS ASSSPSSSRT PQAKTSTPTT DLPIKVDGAN VNITAAIYDE IQQEMKRAKV SQALFAKVAA NKSQGWLCEL LRWKENPSPE NRTLWENLCT IRRFLNLPQH ERDVIYEEES RHHHSERMQH VVQLPPEPVQ VLHRQQSQPT KESSPPREEA PPPPPPTEDS CAKKPRSRTK ISLEALGILQ SFIHDVGLYP DQEAIHTLSA QLDLPKHTII KFFQNQRYHV KHHGKLKEHL GSAVDVAEYK DEELLTESEE NDSEEGSEEM YKVEAEEENA DKSKAAPAET DQR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
  • 基因功能参考文献：
    1. Together, these findings demonstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain that underlie the consolidation and stabilization of context-linked memory. PMID: 27897969
    2. Satb2 is a genetic determinant that mediates proper circuit development in a core sensory-to-motor spinal network. PMID: 27478017
    3. Data indicate two special AT-rich sequence-binding protein 2 (SATB2) sequence variants in two unrelated patients presenting with Rett-like phenotypes. PMID: 26596517
    4. Data show that Satb2 is required by both callosal projection neurons and subcerebral projection neurons for proper differentiation and axon pathfinding. PMID: 25037921
    5. Satb2 and Fezf2 regulation promotes subcerebral projection neuron identity in the developing cerebral cortex PMID: 26324926
    6. Satb2 may also be related to the establishment of species-specific neuropeptide co-phenotypes during postnatal development. PMID: 25239161
    7. Target genes of miR-27a ware significantly up-regulated in Satb2-overexpressing cells. PMID: 24218084
    8. A comprehensive overview of Satb2 expression in the adult mouse brain. PMID: 23386513
    9. The Satb2 proteins are dispensable for X chromosome inactivation in mice. PMID: 23079603
    10. the CB(1) receptor contributes to the generation of deep-layer cortical neurons by coupling endocannabinoid signals from the neurogenic niche to the intrinsic proneurogenic Ctip2/Satb2 axis PMID: 23175820
    11. Our results indicate a cell autonomous and non-cell autonomous role for Satb2 in regulating the adhesive and/or repulsive properties of cerebral pyramidal neurons. PMID: 21885532
    12. Genetic evidence obtained in the mouse confirmed the importance of SATB2 regulation by miR-34b/c PMID: 22564414
    13. SATB2 may play a crucial role in protecting against oxidative stress-induced osteoblast apoptosis. PMID: 22570222
    14. Satb2 recruits Ski to the Ctip2 locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex. PMID: 22334647
    15. The transcription factor Satb2 is expressed by cortical neurons extending axons through the corpus callosum and is a determinant of callosal versus subcortical projection. PMID: 22174821
    16. in SATB2-overexpressed MC3T3-E1 cells,genes closely associated with osteoblast differentiation were identified. PMID: 22166200
    17. SATB2 as the first p63 binding partner that differentially influences AEC and EEC p63 mutant proteins PMID: 21965674
    18. SATB2 acts as a potent transcription factor to enhance osteoblastogenesis and promote bone regeneration. PMID: 21385070
    19. Runx2, a transcription factor essential for osteoblastogenesis, negatively regulates expression of the miR cluster 23a approximately 27a approximately 24-2. PMID: 20980664
    20. The Satb2 gene was down-regulated and the Hoxa2 gene was up-regulated in phenytoin-treated mouse embryonic craniofacial tissue. PMID: 20651846
    21. Satb2 may regulate differentiation of subsets of neurons at the level of higher order chromatin structure via binding to matrix attachment region DNA elements (MARs). PMID: 15733084
    22. SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. PMID: 16751105
    23. Study finds craniofacial defects due to haploinsufficiency of Satb2, including cleft palate (in approximately 25% of cases), phenocopy those seen with 2q32-q33 deletions and translocations in humans PMID: 16960803
    24. We show that at least one VMH marker, the AT-rich binding protein Satb2, was responsive to the loss of leptin signaling (Lep(ob/ob)) at postnatal day 0 but not in the adult. PMID: 18077674
    25. Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. PMID: 18255030
    26. Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. PMID: 18255031

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  • 亚细胞定位：
    Nucleus matrix.
  • 蛋白家族：
    CUT homeobox family
  • 组织特异性：
    Expressed in cortical neurons that extend axons across the corpus callosum. Also expressed in branchial arches and in cells of the osteoblast lineage, but not in chondrocytes and osteoclasts.
  • 数据库链接：

    KEGG: mmu:212712

    STRING: 10090.ENSMUSP00000110057

    UniGene: Mm.145599

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