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  4. Recombinant Mouse Cytochrome P450 3A11 (Cyp3a11)

Recombinant Mouse Cytochrome P450 3A11 (Cyp3a11)

In Stock
  • 货号：
    CSB-EP737360MO
  • 规格：
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Cyp3a11
  • Uniprot No.：
    Q64459
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    65.3 kDa
  • 表达区域：
    1-504aa
  • 氨基酸序列
    MDLVSALSLETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVPRDAVITGA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Cyp3a11 Proteins

靶点详情

  • 功能：
    Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation.
  • 基因功能参考文献：
    1. In het mice, RIF had no effect on plasma lipids composition, CYP27A1 activity, and atherosclerotic plaque development, despite a reduction in cholesterol absorption. In conclusion, the antiatherogenic effect of Cyp3a11 induction by RIF was also dependent on Cyp27a1 expression. PMID: 29191818
    2. lack of Cyp3a has a positive effect on acclimation to a high-fat diet in females as it improves weight gain, glucose response and ketosis. PMID: 29738703
    3. the interactions of quercetin and naringenin with CYP1A and CYP3A in mice liver were not affected by the levels of persistent organic pollutants exposure. PMID: 28567424
    4. Cyp3a is a major determinant of systemic levels of testosterone in mice. PMID: 27137100
    5. Diabetes mellitus caused a decrease in the activity of Cyp3a11-mediated testosterone-6beta-hydroxylation, but no change in the activity of Cyp3a11-mediated midazolam 1-hydroxylation and an increase in the activity of UGT1a9-mediated propofol O-glucuronidation in db/db mice PMID: 27514509
    6. Data (including data from studies using recombinant enzymes/knockout mice) suggest that Cyp3a/Cyp3a11 is primary enzyme in liver microsomes contributing to formation of aldehydes during metabolic inactivation of gefitinib, an antineoplastic agent. PMID: 26212543
    7. The validity of the in vivo model using transgenic mice carrying the human CYP3A4 gene and lacking their own Cyp3a genes (CYP3A4-Tg mice). PMID: 25005602
    8. MC downregulates mouse hepatic CYP3A protein. PMID: 23846873
    9. The findings suggest that reduction of hepatic total cholesterol in Cyp3a(-/-) mice would be the consequence of enhanced bile acid synthesis. PMID: 23709690
    10. CYP3A expression level in the liver is not affected by the intake of a high-fat diet. PMID: 23370405
    11. CYP3A is involved in limiting paclitaxel plasma concentrations after oral administration in mice. PMID: 23090875
    12. Expression of Cyp3a11 was suppressed in hypothyroid C57BL/6 wild type (WT) mice and a further decrement was observed in hypothyroid CAR-/- mice, but not in hypothyroid PXR-/- mice PMID: 22503787
    13. CYP3A activities in transgenic mice were markedly reduced compared to those in wild-type or unrelated miR-shRNA transgenic controls. PMID: 22291988
    14. investigation of substrate specificity of Cyp3a using metabolomics approach: atazanavir is metabolized in vivo to same metabolites as via human recombinant CYP3A; identification of metabolites in mouse urine and feces PMID: 21148252
    15. A deletion of the hepatocyte nuclear factor-4alpha binding motif in liver changes the expression of Cyp3a11. PMID: 20926756
    16. Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain. PMID: 12617959
    17. CYP3a expression is regulated by histidine decarboxylase PMID: 14642533
    18. PXR is involved in induction of drug metabolism through its targeted genes including CYP3A4. PMID: 17936928
    19. Drug metabolizing enzyme induction of Cyp3a11 is reported in experimental fatty liver. PMID: 18488193
    20. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. PMID: 19188337
    21. Cyp3a11 plays a crucial role in directing drug action to hormonal response within the limbic system of mouse brain in drug-hormone crosstalk. PMID: 19226368

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Highly expressed in liver.
  • 数据库链接：

    KEGG: mmu:13112

    STRING: 10090.ENSMUSP00000037665

    UniGene: Mm.332844

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