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  4. Recombinant Mouse Cysteine-rich motor neuron 1 protein (Crim1), partial

Recombinant Mouse Cysteine-rich motor neuron 1 protein (Crim1), partial

  • 中文名称：
    Recombinant Mouse Cysteine-rich motor neuron 1 protein(Crim1) ,partial
  • 货号：
    CSB-YP862411MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine-rich motor neuron 1 protein(Crim1) ,partial
  • 货号：
    CSB-EP862411MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine-rich motor neuron 1 protein(Crim1) ,partial
  • 货号：
    CSB-EP862411MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine-rich motor neuron 1 protein(Crim1) ,partial
  • 货号：
    CSB-BP862411MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine-rich motor neuron 1 protein(Crim1) ,partial
  • 货号：
    CSB-MP862411MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Crim1
  • Uniprot No.：
    Q9JLL0
  • 别名：
    Crim1Cysteine-rich motor neuron 1 protein; CRIM-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
  • 基因功能参考文献：
    1. these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature. PMID: 27803996
    2. Collectively, our data demonstrates that Crim1 is essential for cell-autonomous and paracrine aspects of heart development PMID: 26821812
    3. Crim1 regulates integrin signaling in murine lens development PMID: 26681494
    4. CRIM1 is the causative gene for Colobomatous macrophthalmia with microcornea syndrome and is important for eye development. PMID: 25561690
    5. Report the involvement of both endothelial cells and monocytes in the development of progressive renal fibrosis in Crim1 mutant mice. PMID: 23224993
    6. Crim1 mutations are associated with defects in papillary development and progression to chronic kidney disease later in life. PMID: 22488641
    7. Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells. PMID: 22225908
    8. CRIM1 has a role in capillary formation and maintainance during angiogenesis PMID: 12464430
    9. CRIM1 modulates BMP activity by affecting its processing and delivery to the cell surface PMID: 12805376
    10. Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. PMID: 17106887

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest ex
  • 数据库链接：

    KEGG: mmu:50766

    STRING: 10090.ENSMUSP00000108117

    UniGene: Mm.311912

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