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  4. Recombinant Mouse Cyclin-dependent kinase-like 5 (Cdkl5), partial

Recombinant Mouse Cyclin-dependent kinase-like 5 (Cdkl5), partial

  • 中文名称：
    Recombinant Mouse Cyclin-dependent kinase-like 5(Cdkl5) ,partial
  • 货号：
    CSB-YP005085MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-dependent kinase-like 5(Cdkl5) ,partial
  • 货号：
    CSB-EP005085MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-dependent kinase-like 5(Cdkl5) ,partial
  • 货号：
    CSB-EP005085MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-dependent kinase-like 5(Cdkl5) ,partial
  • 货号：
    CSB-BP005085MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclin-dependent kinase-like 5(Cdkl5) ,partial
  • 货号：
    CSB-MP005085MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdkl5
  • Uniprot No.：
    Q3UTQ8
  • 别名：
    Cdkl5; Cyclin-dependent kinase-like 5; EC 2.7.11.22
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates phosphorylation of MECP2. May regulate ciliogenesis.
  • 基因功能参考文献：
    1. Study provides a comprehensive overview of neurobehavioral phenotypes of heterozygous female Cdkl5 +/- mice and demonstrates that the heterozygous female might be a valuable animal model in preclinical studies on CDKL5 disorder. PMID: 29977282
    2. This study showed that the loss of CDKL5 causes breathing deficiency, supporting a CDKL5-mediated regulation of respiratory function in mice. PMID: 29208534
    3. CDKL5 plays significant roles in regulating emotional behaviors especially on anxiety- and fear-related responses PMID: 29702698
    4. Study generated the Cdkl5 KO mice, and identified hyperexcitability in response to NMDA and postsynaptic overaccumulation of GluN2B-containing NMDARs in the hippocampus. The GluN2B-selective antagonist ifenprodil abrogated the NMDA-induced hyperexcitability of Cdkl5 KO mice. These data indicate that CDKL5 plays an important role in controlling postsynaptic localization of the GluN2B-SAP102 complex in the hippocampus. PMID: 28688852
    5. Findings support that CDKL5 plays a role in the comorbid features of autism and ADHD, and mice lacking CDKL5 may serve as an animal model to study the molecular and circuit mechanisms underlying autism-ADHD comorbidity. PMID: 29016850
    6. data demonstrate that sleep apneas are a core feature of CDKL5 disorder and a respiratory biomarker of CDKL5 deficiency in mice, and suggest that sleep-disordered breathing should be evaluated routinely in CDKL5 patients PMID: 28230307
    7. The data of this study demonstrate that dendritic spine stabilization is strongly regulated by CDKL5. PMID: 26452614
    8. Our findings demonstrate that CDKL5 is an important regulator of synaptic function in glutamatergic neurons and serves a critical role in learning and memory. PMID: 28674172
    9. We have characterised the predominant brain isoform of CDKL5, a 9.7 kb transcript comprised of 18 exons with a large 6.6 kb 3'-untranslated region (UTR), which we name hCDKL5_1. In addition we describe new exonic regions and a range of novel splice and UTR isoforms PMID: 27315173
    10. Taken together, these results strongly suggested that DYRK1A bound to CDKL5 and phosphorylated it on Ser-308, thus interfering with its nuclear localization. PMID: 27840050
    11. CDKL5 deletion during development more markedly impairs the establishment of a correct GABAergic cerebellar network than that of glutamatergic one, leading to the behavioural symptoms associated with CDKL5 mutation. PMID: 27108663
    12. Findings highlight a critical role of CDKL5 in the fundamental processes of brain development, namely neuronal precursor proliferation, survival and maturation PMID: 24952363
    13. Amph1 is the cytoplasmic substrate for CDKL5. PMID: 23651931
    14. CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes. PMID: 23236174
    15. a functional axis between MYCN and CDKL5 governing both neuron proliferation rate and differentiation. PMID: 22921766
    16. CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity. PMID: 22922712
    17. both subcellular localization and expression of CDKL5 are modulated by the activation of extrasynaptic N-methyl-D-aspartate receptors and suggest regulation of CDKL5 by cell death pathways. PMID: 21832092
    18. CDKL5 is involved in pre-mRNA processing, by controlling splicing factor dynamics. PMID: 19740913
    19. CDKL5 phosphorylation is required for its entrance into the nucleus whereas a portion of the COOH-terminal domain is responsible for a stable residency in this cellular compartment probably through protein-protein interactions PMID: 16935860
    20. CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail PMID: 18701457
    21. Cyclin-dependent kinase-like 5 in mouse brain could bind to the N-terminal domain of Dnmt1. PMID: 18977197

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 数据库链接：

    KEGG: mmu:382253

    STRING: 10090.ENSMUSP00000084342

    UniGene: Mm.443717

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