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  4. Recombinant Mouse Contactin-associated protein 1 (Cntnap1), partial

Recombinant Mouse Contactin-associated protein 1 (Cntnap1), partial

  • 中文名称：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 货号：
    CSB-YP005692MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 货号：
    CSB-EP005692MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 货号：
    CSB-EP005692MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 货号：
    CSB-BP005692MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-associated protein 1(Cntnap1) ,partial
  • 货号：
    CSB-MP005692MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cntnap1
  • Uniprot No.：
    O54991
  • 别名：
    Cntnap1; Nrxn4Contactin-associated protein 1; Caspr; Caspr1; MHDNIV; NCP1; Neurexin IV; Neurexin-4; Paranodin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
  • 基因功能参考文献：
    1. E. coli exploits Caspr1 as a host receptor for penetration of the blood-brain barrier, resulting in meningitis PMID: 29895952
    2. In Caspr1 mutants, there was a reduction in conductive properties of peripheral myelinated fibers and neuromuscular junction disintegration. PMID: 28370195
    3. Caspr as a novel key regulator that controls the temporal specification of cell fate in radial glial cells of the developing cerebral cortex through Notch signaling PMID: 26740489
    4. Simultaneous deletion of Caspr and Caspr2 disrupts the internodal organization of Kv1.2. PMID: 25378149
    5. Caspr co-localizes and interacts with APP. Amyloid-beta (Abeta) 40 and Abeta42 generation were also reduced in HEK-APP cells by Caspr overexpression. PMID: 23748076
    6. Caspr labeling was observed through much of the retina, including horizontal, bipolar, amacrine, and ganglion cells. PMID: 21031018
    7. Clustering of Caspr at initial contact sites between OL processes and the axon requires glial expression of NF155 but not of contactin. Expression of membrane proteins along the axolemma is determined by the type of the contacting glial cells. PMID: 19565653
    8. These results suggest that Caspr serves as a "transmembrane scaffold" that stabilizes the Caspr/contactin adhesion complex at the paranodal junction by connecting it to cytoskeletal components within the axon. PMID: 12082082
    9. F3/contactin and caspr/paranodin traffic to the cell surface via a non-conventional pathway PMID: 12972410
    10. Nogo-A interacts in trans with axonal Caspr at CNS paranodes, an interaction that may have a role in modulating axon-glial junction architecture and possibly K(+)-channel localization during development. PMID: 14592966
    11. the Caspr/Cont complex is essential for the formation of axoglial SJ PMID: 17549747
    12. Caspr protein is required for recruitment and retention of KCNQ4 at calyceal synapses in vestibular hair cells. PMID: 19279247
    13. The Caspr gene has been identified in the neurological mutant shambling (shm) mouse and shown to encode the contactin-associated protein, which is a major component of the paranodal junction in myelinated nerves. PMID: 19816196
    14. These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction. PMID: 11395000
    15. Both NCP1 and CGT mutants develop large swellings accompanied by cytoskeletal disorganization and degeneration in the axons of cerebellar Purkinje neurons. PMID: 16551741

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction.
  • 蛋白家族：
    Neurexin family
  • 组织特异性：
    Expressed in brain. In myelinated nerve fibers predominantly found in paranodal axoglial junctions. In the internodal region of myelinated axons in the CNS and the PNS also found as a thin line apposing the inner mesaxon of the myelin sheath. In PNS neuro
  • 数据库链接：

    KEGG: mmu:53321

    STRING: 10090.ENSMUSP00000099398

    UniGene: Mm.474527

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