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  4. Recombinant Mouse Contactin-1 (Cntn1), partial

Recombinant Mouse Contactin-1 (Cntn1), partial

  • 中文名称：
    Recombinant Mouse Contactin-1(Cntn1) ,partial
  • 货号：
    CSB-YP005686MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-1(Cntn1) ,partial
  • 货号：
    CSB-EP005686MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-1(Cntn1) ,partial
  • 货号：
    CSB-EP005686MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-1(Cntn1) ,partial
  • 货号：
    CSB-BP005686MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-1(Cntn1) ,partial
  • 货号：
    CSB-MP005686MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cntn1
  • Uniprot No.：
    P12960
  • 别名：
    Cntn1Contactin-1; Neural cell surface protein F3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
  • 基因功能参考文献：
    1. Data indicate that Contactin-1 expression is dependent upon EBF factors; Cntn1 gene belongs to the expanding regulatory cascade driven by these transcriptional regulators so that changes in its activation may contribute to the Ebf2 null mutant phenotype PMID: 25820347
    2. It plays a role in hippocampal synaptic plasticity and memory also in aged mice, suggesting that it acts on molecular pathways related to apoptosis and amyloid-beta production. PMID: 25659859
    3. The F3/contactin plays a role in promoting adult hippocampal neurogenesis and that this effect correlates with improved synaptic function and memory. PMID: 23939883
    4. Contactin-1 has roles in regulating myelination and nodal/paranodal domain organization in the central nervous system PMID: 24385581
    5. In developing cerebral cortex and basal ganglia the F3/Contactin gene is mostly activated during early commitment of neuronal precursors. PMID: 22579730
    6. The phenotype of the Cntn1 mice arises from dysfunction in the brain, spinal cord or peripheral nervous system. PMID: 22242131
    7. Data show that TAG1 and F3 act antagonistically to control SHH-induced proliferation: F3 suppresses SHH-induced GNP proliferation and induces differentiation, whereas TAG1 antagonises F3. PMID: 21205796
    8. The structural and functional properties, the mechanisms driving the regulated expression and on the developmental role of mouse F3/Contactin is reviewed. PMID: 19372728
    9. these findings indicate that precise spatio-temporal regulation of TAG-1 and F3/contactin expression is critical for normal cerebellar morphogenesis PMID: 12441289
    10. F3/contactin and caspr/paranodin traffic to the cell surface via a non-conventional pathway PMID: 12972410
    11. Deficits in sensorimotor function, homing behavior, and motor activity in transgenic F3/contactin mice indicate that the finely coordinated expression of F3/contactin is key to the functional, as well as morphological maturation of the cerebellum. PMID: 14667450
    12. These data provide evidence of a role for contactin in selectively regulating the cell surface expression and current densities of TTX-R but not TTX-S Na+ channel isoforms in nociceptive DRG neurons. PMID: 16029194
    13. Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. PMID: 19075012
    14. Thus, our results suggest a contribution by DRG Na(v)1.6, and possibly Contactin to neuropathic pain in the neuroma model in mice. PMID: 19524556

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 组织特异性：
    Expressed in the ovary and in Sertoli cells of the testis.
  • 数据库链接：

    KEGG: mmu:12805

    STRING: 10090.ENSMUSP00000000109

    UniGene: Mm.470343

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