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  4. Recombinant Mouse Complement C5 (C5), partial

Recombinant Mouse Complement C5 (C5), partial

  • 中文名称：
    Recombinant Mouse Complement C5(C5) ,partial
  • 货号：
    CSB-YP003995MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Complement C5(C5) ,partial
  • 货号：
    CSB-EP003995MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Complement C5(C5) ,partial
  • 货号：
    CSB-EP003995MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Complement C5(C5) ,partial
  • 货号：
    CSB-BP003995MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Complement C5(C5) ,partial
  • 货号：
    CSB-MP003995MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C5
  • Uniprot No.：
    P06684
  • 别名：
    C5; HcComplement C5; Hemolytic complement) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 表达区域：
    19-674
  • 氨基酸序列
    QE QTYVISAPKI LRVGSSENVV IQVHGYTEAF DATLSLKSYP DKKVTFSSGY VNLSPENKFQ NAALLTLQPN QVPREESPVS HVYLEVVSKH FSKSKKIPIT YNNGILFIHT DKPVYTPDQS VKIRVYSLGD DLKPAKRETV LTFIDPEGSE VDIVEENDYT GIISFPDFKI PSNPKYGVWT IKANYKKDFT TTGTAYFEIK EYVLPRFSVS IELERTFIGY KNFKNFEITV KARYFYNKVV PDAEVYAFFG LREDIKDEEK QMMHKATQAA KLVDGVAQIS FDSETAVKEL SYNSLEDLNN KYLYIAVTVT ESSGGFSEEA EIPGVKYVLS PYTLNLVATP LFVKPGIPFS IKAQVKDSLE QAVGGVPVTL MAQTVDVNQE TSDLETKRSI THDTDGVAVF VLNLPSNVTV LKFEIRTDDP ELPEENQASK EYEAVAYSSL SQSYIYIAWT ENYKPMLVGE YLNIMVTPKS PYIDKITHYN YLILSKGKIV QYGTREKLFS STYQNINIPV TQNMVPSARL LVYYIVTGEQ TAELVADAVW INIEEKCGNQ LQVHLSPDEY VYSPGQTVSL DMVTEADSWV ALSAVDRAVY KVQGNAKRAM QRVFQALDEK SDLGCGAGGG HDNADVFHLA GLTFLTNANA DDSHYRDDSC KEIL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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C5 ELISA kits

靶点详情

  • 功能：
    Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
  • 基因功能参考文献：
    1. In mice that lost the ability to express complement C5, there was a lower frequency of metastasis, and males no longer had a higher frequency of metastasis than females. PMID: 27105526
    2. C5 contributes effectively to liver steatosis and inflammation in non-alcoholic fatty liver disease pathogenesis PMID: 27477770
    3. C5a in vitro caused activation (phosphorylation) of MAPKs and Akt in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt in heart. PMID: 28572445
    4. data suggest a novel role for the anaphylatoxin C5a as a master switch of the delicate pHi balance in neutrophils resulting in profound inflammatory and metabolic changes that contribute to hyperlactatemia during sepsis. PMID: 28490576
    5. n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent. PMID: 27437704
    6. We induced anti-myeloperoxidase vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease PMID: 27235854
    7. Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner. PMID: 27029558
    8. Carboxypeptidase B2 deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model. PMID: 25851247
    9. In mice, loss of C5 or injection of a C5a-receptor antagonist significantly reduced the level of fibrosis of chronic pancreatitis. PMID: 26001927
    10. C5a signaling increases the expression of the chemokine monocyte chemoattractant protein-1 in hepatic metastases of colon cancer PMID: 25739439
    11. C5a produced during lung injury binds to C5aR in alveolar macrophages, initiates downstream signaling that promotes autophagy. PMID: 25032853
    12. Loss of C5a is associated with atherosclerotic plaques. PMID: 25124749
    13. Protein kinase C-delta mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages PMID: 24682410
    14. Activation of the complement cascade (ComC) and cleavage of C5 by C5 convertase are enabling events in the release of C5a that plays a crucial role in the egress of hematopoietic stem cells from bone marrow. PMID: 24667943
    15. Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. PMID: 25172497
    16. The C5(-/-) mice displayed significantly reduced lumenal inflammatory infiltration and cytokine production in oviduct tissue, suggesting that C5 may contribute to chlamydial induction of hydrosalpinx by enhancing inflammatory responses. PMID: 24842924
    17. Complement component C5a contributes to fetal cortical brain injury in a mouse model of preterm birth. PMID: 24184716
    18. C5 plays an important role in glaucoma, with its deficiency lessening disease severity. PMID: 23806181
    19. C5a regulates IL-12(+)dendritic cell migration to induce pathogenic Th1 and Th17 cells in sepsis. PMID: 23936099
    20. lipocalin OmCI ameliorates murine immune complex-induced acute lung injury in a process involving inhibition of LTB4 and C5 PMID: 23625922
    21. component 5a has a role in vascular integrity and airway remodeling PMID: 23530212
    22. C5a generating enzyme included in cowshed dust extract (CDE) might account for some of the allergy protective effects of CDE by generation of C5a in murine lungs. PMID: 23093649
    23. unilateral uterine ischemia/reperfusion results in bilateral fetal loss and fetal growth restriction, mediated by a systemic mechanism. In the current model, this pathological process is completely dependent on intact complement component 5. PMID: 22688254
    24. The presence of C5a in tumor-bearing mice renders naive innate leukocytes more cytotoxic to tumor cells, and indicates C5a has activating potential of naive neutrophils and/or natural killer (NK) cells for superior effector function. PMID: 22914051
    25. C5a robustly suppresses IL-27(p28) gene expression and release in peritoneal macrophages. PMID: 22491257
    26. These results strongly suggest that the complement component 5 (C5) plays a critical role in early protective inflammatory response to infection with Taenia crassiceps. PMID: 22206032
    27. C5 deficiency leads to attenuated inflammation and normalized MMP-9 activity concomitantly with a significant reduction of fibrosis. PMID: 22277671
    28. IL-17F was produced in peritoneal macrophages after TLR4 activation, peaking after 12 h. This effect was completely dependent on the presence of MyD88. The copresence of the complement activation product C5a amplified IL-17F production. PMID: 21859896
    29. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22199395
    30. P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22057273
    31. Data demonstrate that high locally generated C5a levels are present in wounds for at least 72 hours after incision. PMID: 21736743
    32. Dysregulation of complement C5 in synovial joints has a key role in the pathogenesis of osteoarthritis. PMID: 22057346
    33. C5a alters blood-brain barrier integrity by signaling through CD88 and thereby disturbs the brain microenvironment. PMID: 21929539
    34. Our results identify C5aR activation as a novel pathway driving detrimental effects of NKT and NK cells during early experimental sepsis. PMID: 22058413
    35. Complement component 5 contributes to poor disease outcome in a pneumococcal meningitis model. PMID: 21926466
    36. Complement C5b-9 induce a JNK/Bid-dependent and JNK-independent necrotic cell death. PMID: 19864026
    37. The development of atypical hemolytic uremic syndrome depends on complement C5. PMID: 21148255
    38. Antibody-mediated blockade of C5, treatment with C5a Receptor antagonist, or C5a Receptor deficiency in mice resulted in enhanced pathological retina angiogenesis. PMID: 20625009
    39. these data provide compelling evidence for a protective role of C5a during bloodstream infection by Staphylococcus aureus. PMID: 20375626
    40. The data suggest that complement activation by exogenous or endogenous stimulation can initiate Th17 cell differentiation and expansion in certain autoimmune diseases and presumably in microbial infections. PMID: 20457757
    41. C5a participates in the regulation of IL-17 secretion by gammadelta T cells following sepsis after cecal ligation and puncture. C5a acted on DC, which subsequently induced T cells to secrete IL-17. PMID: 20140904
    42. Complement Ca activates expression of the mRNA encoding cyclooxygenase 2 but not cyclooxygenase 1 in the hypothalamus. PMID: 19800413
    43. function in regulating the inhibitory/activating FcgammaRII/III receptor pair to connect complement and FcgammaR effector pathways in immune inflammation PMID: 12488432
    44. C5 may be required for the limitation of inflammatory response within the central nervous system. PMID: 15033785
    45. Complement C5 may be required in experimental autoimmune encephalomyelitis for clearance of apoptotic inflammatory cells and protection of oligodendrocytes from Fas-dependent apoptosis, possibly through activation of the terminal C5b-9 complex. PMID: 15100315
    46. causative role of C5 deficiency in the dysregulated cytokine response to Candida albicans PMID: 15385488
    47. genome scan provides additional evidence confirming the role of C5 as a probable candidate gene for collagen-induced arthritis 2 and collagen-induced arthritis 4 loci PMID: 15529344
    48. C5 has a causal role in fibrogenesis across species PMID: 15995705
    49. plays a significant role in mediation of chemotactic and activation events during mycobacterial infection PMID: 16101818
    50. data suggest that, in the genetic absence of C3, thrombin substitutes for the C3-dependent C5 convertase to produce C5a; this linkage between the complement and coagulation pathways may represent a new pathway of complement activation PMID: 16715088

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:15139

    STRING: 10090.ENSMUSP00000028233

    UniGene: Mm.2168

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