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  4. Recombinant Mouse Collagen alpha-1 (III) chain (Col3a1), partial

Recombinant Mouse Collagen alpha-1 (III) chain (Col3a1), partial

  • 中文名称：
    Recombinant Mouse Collagen alpha-1(III) chain(Col3a1) ,partial
  • 货号：
    CSB-YP005740MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(III) chain(Col3a1) ,partial
  • 货号：
    CSB-EP005740MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(III) chain(Col3a1) ,partial
  • 货号：
    CSB-EP005740MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(III) chain(Col3a1) ,partial
  • 货号：
    CSB-BP005740MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(III) chain(Col3a1) ,partial
  • 货号：
    CSB-MP005740MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Col3a1
  • Uniprot No.：
    P08121
  • 别名：
    Col3a1Collagen alpha-1(III) chain
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
  • 基因功能参考文献：
    1. Results show that COL1A1 and COL3A1 expression is up-regulated in Schistosoma japonicum-induced liver fibrosis. Furthermore, miR-29b directly targets COL1A1 and COL3A1 through binding to their 3'UTR. PMID: 29091295
    2. findings suggest that deficiencies of leucine and isoleucine reduce type I and III tropocollagen syntheses in skin by suppressing the action of mTOR PMID: 29191093
    3. osthole could inhibit the collagen I and III expressions and their ratio in CFs treated with TGF-beta1 via Smad signaling pathway, which might be one of its anti-fibrotic action mechanisms. PMID: 27870967
    4. The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB activation and oxidative stress. PMID: 27648120
    5. Tsk2 expressing mice harbor numerous autoantibodies in their plasma, including some which are similar to antinuclear antibodies present in systemic sclerosis patients. PMID: 16081813
    6. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. PMID: 24820199
    7. Procollagen type III amino-terminal propeptide increases with left ventricular dilation and decreases with improvement in systolic function in paediatric dilated cardiomyopathy, indicating a role as a biomarker of cardiac remodelling in children. PMID: 24192074
    8. Tsk2 point mutation is the first documented gain-of-function mutation associated with Col3a1, which leads instead to fibrosis. PMID: 25330296
    9. Col3 plays a role in development of trabecular bone through its effects on osteoblast differentiation PMID: 24626604
    10. Type I collagen turnover is critical to large pulmonary artery remodeling during hypoxic pulmonary hypertension when collagen metabolism is not mutated and type III collagen may serve as a reserve. PMID: 23377784
    11. Our findings demonstrated the extreme sensitivity of Col3a1 insufficient mice to prematurely develop thoracic aortic ruptures in response to AngII and its associated high levels in BP. PMID: 23630948
    12. a possible common pathological pathway linking connective tissue diseases and brain malformations PMID: 22235340
    13. Data show that that Col3a1 null mutant mice exhibit overmigration of neurons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the phenotype seen in Gpr56 null mutant mice. PMID: 21768377
    14. Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing PMID: 21252470
    15. Spontaneous deletion in the promoter region and exons 1-39 of the murine Col3a1 locus has produced a relevant and exploitable model of the vascular dissection in vascular Ehlers-Danlos syndrome. PMID: 21071432
    16. Data indicate that COL3A1 intronic miRNAs may regulate the expression of other collagen genes in development. PMID: 21268075
    17. Transcriptional activation in Tsk2/+ dermal fibroblasts. PMID: 12659831
    18. This study shows the presence of collagen types I, III, and V in the endometrial stroma of implantation and interimplantation sites from days 5 to 8 of pregnancy in the mouse. PMID: 17453912
    19. alterations in procollagen expression (specifically 1alpha1 and 3) may contribute to a pattern of collagen deposition in the mid-gestational fetuses that is more favorable for scarless healing with less type 1 and more type 3 collagen. PMID: 17950069
    20. decreased expression in late-gestational fibroblasts PMID: 19560165

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 组织特异性：
    Expressed in embryonic brain, specifically in the meninges, pial basement membrane and blood vessels (at protein level).
  • 数据库链接：

    KEGG: mmu:12825

    STRING: 10090.ENSMUSP00000085192

    UniGene: Mm.249555

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