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  4. Recombinant Mouse Collagen alpha-1 (II) chain (Col2a1), partial

Recombinant Mouse Collagen alpha-1 (II) chain (Col2a1), partial

  • 中文名称：
    Recombinant Mouse Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-YP005739MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-EP005739MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-EP005739MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-BP005739MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Collagen alpha-1(II) chain(Col2a1) ,partial
  • 货号：
    CSB-MP005739MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Col2a1
  • Uniprot No.：
    P28481
  • 别名：
    Col2a1Collagen alpha-1(II) chain; Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
  • 基因功能参考文献：
    1. this study's findings indicate that endothelial Del-1 not influence atherosclerosis development in ApoE(-/-) mice PMID: 28796274
    2. Overexpression of Dlx2 enhances early chondrocyte differentiation by increasing accumulation of Col2alpha1, type II collagen and aggrecan, but interferes later stages of chondrocyte differentiation through inhibiting MMP13 expression. PMID: 29787757
    3. Detection of transcripts of Collagen type2 A1 (Col2a1) revealed that both e trabecular cartilageand the anterior part of the hypophyseal cartilage developing anterior to the persistent epithelial stalk of the anterior lobe of the pituitary gland were suppressed in the Foxc1(ch/ch) . PMID: 29322554
    4. found bone destruction and bone loss phenotype in vertebral bone in beta-catenin(Col2CreER) KO mice PMID: 29230102
    5. Kartogenin effectively increased the expression of Col II and aggrecan in hNPCs and slowed the degeneration of intervertebral discs stimulated by IL-1b and TNF-a PMID: 29207013
    6. These findings suggest a novel mechanism of action of SOX5/6; namely, the SOX9/5/6 combination enhances Col2a1 transcription through a novel enhancer in intron 6 together with the enhancer in intron 1. PMID: 27881681
    7. this study shows role of Del-1 in the regulation of platelet-monocyte interplay and the subsequent heterotypic aggregate formation in the blood-mediated inflammatory reaction in islet transplantation PMID: 26676803
    8. Alpha-tectorin and beta-tectorin crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus. PMID: 26806019
    9. Col2 expression was seen in the prehypertrophic zone of the mandibular condyle cartilage. PMID: 26362410
    10. Rspo2 activates Wnt/beta-catenin signaling to reduce Col2a1 and Sox9 and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage PMID: 27012200
    11. The MC13 mutation in Col2a1 causes an incompletely penetrant splicing defect. PMID: 25541700
    12. The mutant G1170S Col2a1 gene in mice clearly alters the transgenic murine phenotype and cartilage matrix homeostasis. PMID: 24168833
    13. Data indicate that tamoxifen decreased collage type II COL2A1 by activating matrix metallopeptidases MMP-2/13 expression. PMID: 25703139
    14. a mouse of model of spondyloepiphyseal dysplasia is associated with the R992C substitution in collagen II PMID: 25451152
    15. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA during scleral chondrogenesis accompany myopia development. PMID: 25684979
    16. Results indicate the ability of type II collagen (CII) to generate CII-specific anterior chamber-associated immune deviation (ACAID)-mediated immune tolerance in vivo and in vitro in both DBA/1 mice and C57BL/6 mice. PMID: 25211510
    17. expression of the Col2a1 IIC splice form may have a regulatory function in controlling alternative splicing of exon 2 to generate defined proportions of IIA, IID and IIB procollagen isoforms during cartilage development PMID: 24735995
    18. regulates Mac-1-mediated complement-dependent phagocytosis PMID: 24352615
    19. characterization of the Col2a1(+ex2) mice has surprisingly shown that disruption of alternative splicing does not affect overt cartilage formation PMID: 24113490
    20. Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model. PMID: 24475193
    21. Type II collagen induces peripheral tolerance in BALB/c mice via the generation of CD8+ T regulatory cells PMID: 23133648
    22. An autoimmune response to CII can disrupt articular cartilage, particularly that of the small joints, and the subsequent integrity of the cartilage depends on a balance between breakdown and repair. PMID: 23239042
    23. Lef1 mediated looping between promoter and 3' UTR under the permissive chromatin architecture upregulates Col2a1 expression in primary chondrocytes. PMID: 22815835
    24. A mouse model with a Ser1386Pro mutation of the Col2a1 C-propeptide domain that results in abnormal collagen processing and phenotypic features consistent with spondyloepiphyseal dysplasia congenita and secondary osteoarthritis has been established. PMID: 22028304
    25. SOX9 regulates chondrocyte differentiation, proliferation.. It directly transactivates Col2a1 enhancing this gene's expression in immature/proliferating chondrocytes. PMID: 22072985
    26. B cell-reactive epitopes on collagen II (CII)are largely shared between human rheumatoid arthritis and rodent CII-induced arthritis. PMID: 21940677
    27. beta2-adrenergic receptors inhibit the expression of collagen type II in growth plate chondrocytes by stimulating the AP-1 factor Jun-B. PMID: 21177286
    28. Data show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced transcript of Col2a1, is expressed in the prechordal plate and the anterior definitive endoderm. PMID: 20730911
    29. Down-regulation of Col2a1 is associated with autoimmune type 1 diabetes mellitus. PMID: 20414703
    30. Study identified 57 novel mutations including missense changes in both COL2A1 and COL11A1. PMID: 20513134
    31. The relative expressions of type IIB to type IIA procollagens are good markers to define the differentiation state of chondrocytes. PMID: 20129696
    32. decreased production in LPS-treated chondrocytes treated with low molecular mass hyaluronan PMID: 19710088
    33. a new long form cooperates with Sox9 to activate the type II collagen gene. (Lc-maf protein) PMID: 12381733
    34. Snail family members, Snail (Sna) and Slug (Slugh), are involved in chondrocyte differentiation by controlling the expression of type II collagen (Col2a1) and aggrecan. PMID: 12917416
    35. A missense mutation in the Col2a1 gene has been discovered, resulting in a phenotype of spondyloepiphyseal dysplasia congenita. Adult homozygous mutant animals have shortened noses, dysplastic vertebrae, femora, and tibias, retinoschisis and hearing loss. PMID: 12968670
    36. Col2a1 mutant mice have a complete absence of mature type II collagen in the homozygote cartilage and an insufficiency of type II collagen in the heterozygote cartilage PMID: 14614991
    37. MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development PMID: 15778499
    38. cis elements in the COL2A1 gene modulate the cell type-specific alternative splicing switch of exon 2 during cartilage development PMID: 16076844
    39. IGF-I from cells expressing procollagen type IIalphaI regulates bone accretion that occurs during postnatal growth period. PMID: 17519362
    40. this novel form of combined pituitary hormone deficiency is characterized by the perturbation of the hypothalamus-pituitary growth axis, associated with retarded chondrocyte development and enchondral ossification in the epiphyseal growth plate PMID: 17591962
    41. Type II collagen proteolysis is an important determinant for the skeletal outgrowth in mouse embryos through modulation of chondrocyte survival and cartilagenous growth. PMID: 17652426
    42. Data demonstrate that conditional ablation of the Kif3a or Pkd1 genes encoding primary cilium/intraflagellar transport-associated proteins using type II collagen-specific Cre transgenic strain results in a severe form of polycystic kidney disease in mice. PMID: 18579360
    43. C-propeptide mutation could interrupt the normal assembly and secretion of Type II procollagen trimers, resulting in a buildup of proalpha1(II) chains in the RER and a reduced rate of matrix synthesis. PMID: 18678883
    44. MT1-MMP activity in the type II collagen-expressing cells of the skeleton rescues not only diminished chondrocyte proliferation, but also results in amelioration of the severe skeletal dysplasia associated with MT1-MMP deficiency. PMID: 19419317
    45. Data reveal that COL2 is attacked at a susceptible peptide bond at the surface of developing articular cartilage canals, and is cleaved by MMP-13. PMID: 19441084

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  • 相关疾病：
    Defects in Col2a1 are the cause of a phenotype resembling human spondyloepiphyseal dysplasia congenita (sedc). Homozygous sedc mice can be identified at birth by their small size and shortened trunk. Adults have shortened noses, dysplastic vertebrae, femora and tibias, and retinoschisis and hearing loss.
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 数据库链接：

    KEGG: mmu:12824

    STRING: 10090.ENSMUSP00000023123

    UniGene: Mm.2423

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