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  4. Recombinant Mouse Cocaine- and amphetamine-regulated transcript protein (Cartpt)

Recombinant Mouse Cocaine- and amphetamine-regulated transcript protein (Cartpt)

  • 中文名称：
    Recombinant Mouse Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 货号：
    CSB-YP004532MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 货号：
    CSB-EP004532MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 货号：
    CSB-EP004532MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 货号：
    CSB-BP004532MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 货号：
    CSB-MP004532MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cartpt
  • Uniprot No.：
    P56388
  • 别名：
    Cartpt; CartCocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-52); CART(55-102); CART(62-102)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-129
  • 氨基酸序列
    QED AELQPRALDI YSAVDDASHE KELPRRQLRA PGAMLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ CAVRKGARIG KLCDCPRGTS CNSFLLKCL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.
  • 基因功能参考文献：
    1. The potential mechanism of CART was determined to be associated with inflammatory cytokines and related apoptotic genes. CART therefore appears to be associated with DA in its effect on ischemic stroke and is protective against brain injury following ischemic stroke by reducing inflammation activation PMID: 30066844
    2. Study showed that the perikarya and central terminals of vagal afferents are invariably enriched in CART and devoid of melanin-concentrating hormone and that neuropeptidergic profile of the CART-positive vagal afferents is remarkably stable across the energy balance spectrum. PMID: 27822503
    3. Study conclude that CART is a regulator of glucose homeostasis and could play an important role in the pathophysiology of type 2 diabetes. Based on the ability of CART to increase insulin secretion and reduce glucagon secretion, CART-based agents could be a therapeutic modality in type 2 diabetes. PMID: 27338624
    4. Taken together, these results demonstrate that CART is a critical regulator of energy expenditure, energy partitioning and utilization dependent on the thermal environment. PMID: 27080622
    5. Collectively, our main findings indicate that high-fat diet induced-hypertension and autonomic imbalance are associated to an upregulation of CART levels in the dorsomedial hypothalamus of mice. PMID: 27273815
    6. Leptin induced CART negatively affects intracellular cAMP levels, MAPK signaling, and aromatase mRNA expression, which leads to lower estradiol synthesis in granulosa cells and altered ovarian folliculogenesis. PMID: 26730935
    7. 100 mg/kg caffeine increased CART 2 h after administration in nucleus accumbens shell, dorsal bed nucleus of the stria terminalis, central nucleus of the amygdala, paraventricular hypothalamic nucleus, arcuate hypothalamic nucleus, and locus coeruleus. PMID: 25820086
    8. The present study demonstrates a role for CART in ethanol consummatory behaviors. PMID: 22823101
    9. CART exerts a neuroprotective effect via inhibition of post-spinal cord injury astrogliosis. PMID: 23151374
    10. CART is an antioxidant peptide PMID: 22235287
    11. CART expression is observed in loose clusters of spinocerebellar mossy fibers in the mouse anterior and posterior zones. PMID: 21452228
    12. leptin modulates arcuate cocaine- and amphetamine-regulated transcript expression in obese A(y)/a mice PMID: 11882520
    13. studies indicate that the CART proximal promoter lies within the 5'-most 641 bp and that in GH3 cells the CART gene is regulated via a cyclic AMP-dependent pathway PMID: 11948252
    14. Review. The genetics of CART and its role in reward, stress, and feeding behavior are reviewed. PMID: 12147208
    15. CART-producing cells are involved in energy homeostasis in the hypothalamus PMID: 12213131
    16. Processing of pro-CART revealed that PC2 is more potent than PC1/3 in generating bioactive CART I; bioactive CART II is solely generated by PC2; and PC1/3 is predominantly active in liberating the two intermediate CART fragments, 33-102 and 10-89. PMID: 12584191
    17. Results provide evidence that the calcium response element of the cocaine- and amphetamine-regulated transcript (CART) proximal promoter is involved in cyclic AMP/protein kinase A/CREB regulation in cells having a neuronal phenotype. PMID: 15207912
    18. CART ('cocaine amphetamine regulated transcript'), a neuropeptide whose expression is controlled by leptin and nearly abolished in ob/ob mice, inhibits bone resorption by modulating Rankl expression PMID: 15724149
    19. CART has a role in the control of appetite [review] PMID: 16102267
    20. observations are compatible with cocaine- and amphetamine-related transcript (CART) being a downstream mediator of the cannabinoid receptors (CB1) mediated orexigenic effect of endogenous anandamide PMID: 16131814
    21. analysis of CART binding sites on HepG2 cells and mouse hypothalamic dissociated cells PMID: 16309793
    22. CART signaling is the main molecular pathway accounting for the decrease in bone resorption leading to high bone mass in mice and humans deficient in Mc4r PMID: 16614075
    23. In its capacity of a regulator of bone remodeling, CART may act more as a circulating molecule than a neuropeptide. PMID: 18450969
    24. The decrease of CART mRNA expression in Arc and PVN regions of DIO mice contributes to obesity. CART in the dorsomedial nucleus of hypothalamus and lateral hypothalamus are involved in the orexigenic effect. PMID: 18455834
    25. While central, neuroendocrine regulation of bone mass via CART signaling may have effects on trabecular mass, absence of CART expression does not significantly alter cortical bone geometry, density, or strength. PMID: 18622083
    26. The synergistic long-lasting effect of the CART peptide and CCK on food intake and their additive effect on Fos immunoreactivity in their common targets suggest cooperation of CART peptide and CCK possibly related to the effect of leptin on CCK satiety. PMID: 18939974

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    CART family
  • 数据库链接：

    KEGG: mmu:27220

    STRING: 10090.ENSMUSP00000022150

    UniGene: Mm.75498

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