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  4. Recombinant Mouse Chloride channel protein 2 (Clcn2), partial

Recombinant Mouse Chloride channel protein 2 (Clcn2), partial

  • 中文名称：
    Recombinant Mouse Chloride channel protein 2(Clcn2) ,partial
  • 货号：
    CSB-YP882595MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein 2(Clcn2) ,partial
  • 货号：
    CSB-EP882595MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein 2(Clcn2) ,partial
  • 货号：
    CSB-EP882595MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein 2(Clcn2) ,partial
  • 货号：
    CSB-BP882595MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein 2(Clcn2) ,partial
  • 货号：
    CSB-MP882595MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clcn2
  • Uniprot No.：
    Q9R0A1
  • 别名：
    Clcn2; Clc2Chloride channel protein 2; ClC-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis.
  • 基因功能参考文献：
    1. High fat diet -treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding protein (SREBP)-1c expression and its downstream targeting enzymes such as fatty acid synthase (FAS), HMG-CoA reductase (HMGCR) and acetyl-Coenzyme A carboxylase (ACCalpha). PMID: 29550812
    2. Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase, reduced tubulovesicles and reduced stimulated acid secretion. PMID: 26378782
    3. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule GlialCAM and chloride channel ClC-2, and for changing ClC-2 currents. PMID: 24647135
    4. Loss of ClC-2 is associated with increased development of DSS-induced colitis. PMID: 24030525
    5. fast gate protonation was V(m) and Cl(-) independent and the equilibrium constant for closed-open transition of unprotonated channels was facilitated by elevated [Cl(-)](i) in a V(m)-dependent manner PMID: 22753549
    6. The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1), K(2P) channels (TREK-1 and TWIK-1) and Cl- channels (ClC2). PMID: 22253765
    7. ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl. PMID: 22079595
    8. permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel. PMID: 20498235
    9. GABAA receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons. PMID: 20676104
    10. ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase appear to be important to the function of ClC-2 in normal mucosa. PMID: 20489043
    11. these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus PMID: 20116415
    12. Heterozygous nmf240 mice present with a reduced electroretinography light peak component suggests that CLCN2 is necessary for the generation of this response component. PMID: 20071672
    13. we suggest a dual role for ClC-2 in neurons, providing an additional efflux pathway for chloride and constituting a substantial part of the background conductance, which regulates excitability. PMID: 20357128
    14. ClC-2 is unlikely to be a candidate rescue channel in cystic fibrosis PMID: 15007059
    15. activation of host ClC-2 channels participates in the altered permeability of Plasmodium-infected erythrocytes but is not required for intraerythrocytic parasite survival PMID: 15272009
    16. This study concluded that Clcn2is the inward-rectifying chloride channel in duct cells, but its expression is not apparently required for the ion reabsorption or the barrier function of salivary ductal epithelium. PMID: 18801913
    17. These data demonstrate a pivotal role of ClC-2 in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury. PMID: 18976652

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-2/CLCN2 subfamily
  • 组织特异性：
    Expressed in the adrenal gland and brain.
  • 数据库链接：

    KEGG: mmu:12724

    STRING: 10090.ENSMUSP00000007207

    UniGene: Mm.177761

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