Recombinant Mouse Chitinase-like protein 4 (Chil4)

货号：

CSB-MP842057MO
规格：

￥3960
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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纯度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Chil4
Uniprot No.：

Q91Z98
种属：

Mus musculus (Mouse)
蛋白长度：

Full Length of Mature Protein
来源：

Mammalian cell
分子量：

71.8 kDa
表达区域：

22-402aa
氨基酸序列

YQLMCYYTSWAKDRPTEGSFKPGNIDPCLCTHLIYAFAGMKNNEITYLSEQDLRDYEALNGLKDRNTELKTLLAIGGWKFGPAPFSSMVSTPQNRQTFIKSVIRFLRQYNFDGLNLDWQYPGSRGSPPKDKHLFSVLVQEMRKAFEEESTLNHIPRLLLTSTGAGFIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKNGYTGENSPLYKSPYDIGKSADLNVDSIITYWKDHGAASEKLIVGFPAYGHTFILSDPSKNGIGDPTVSAGPPGKYTNEQGLLAYFEICTFLNEGATEIFDATQEVPYAYLGNEWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQGRFPLTTTLKRDLNVHSASCKASYRGEL
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

C-terminal hFc-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

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功能：

Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity.
基因功能参考文献：
1. Induced only in the presence of IL-4. PMID: 16174095
2. Quantitative RT-PCR demonstrated a 976-fold increase of Chi3l4 mRNA expression and a 24-fold increase of Chi3l3 mRNA expression in the skin of cpdm/cpdm mice. PMID: 16984263
3. Production of Ym1/2 in response to interleukin-13 promotes T helper type (Th)2 cell cytokine production and allergic airway inflammation by inhibiting the production of 12(S)-hydroxyeicosatetraenoic acid (HETE) by 12/15(S)-lipoxygenase (LOX). PMID: 19380786
4. The eosinophilic protein Ym2 (chitinase 3-like 4) was isolated from characteristic hyaline gastric lesion mainly found in female CYP1A2-null mice. The relation between Ym2 and CYP1A2 is unknown. PMID: 11141507
亚细胞定位：

Secreted. Cytoplasm. Note=Detected in the cytoplasm of keratinocytes.
蛋白家族：

Glycosyl hydrolase 18 family, Chitinase class II subfamily
组织特异性：

Detected in stratified squamous epithelium in the junctional region between forestomach and glandular stomach (at protein level). Expression is mainly restricted to stomach.
数据库链接：

KEGG: mmu:104183

STRING: 10090.ENSMUSP00000080851

UniGene: Mm.425140

Recombinant Mouse Chitinase-like protein 4 (Chil4)

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