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  4. Recombinant Mouse Catenin delta-2 (Ctnnd2), partial

Recombinant Mouse Catenin delta-2 (Ctnnd2), partial

  • 中文名称：
    Recombinant Mouse Catenin delta-2(Ctnnd2) ,partial
  • 货号：
    CSB-YP006173MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-2(Ctnnd2) ,partial
  • 货号：
    CSB-EP006173MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-2(Ctnnd2) ,partial
  • 货号：
    CSB-EP006173MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-2(Ctnnd2) ,partial
  • 货号：
    CSB-BP006173MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-2(Ctnnd2) ,partial
  • 货号：
    CSB-MP006173MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ctnnd2
  • Uniprot No.：
    O35927
  • 别名：
    Ctnnd2; Catnd2; NprapCatenin delta-2; Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of canonical Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33.
  • 基因功能参考文献：
    1. delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions. PMID: 25724647
    2. Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation. PMID: 24727894
    3. Delta-catenin occurs in mouse brain dendrites along with PSD-95 in postsynaptic scaffolds. It forms stable complexes with glutamate receptors, suggesting a link between delta-catenin and glutamatergic synaptic transmission during neuronal development. PMID: 12453475
    4. PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability. PMID: 17097608
    5. conditional targeting of p120 catenin in mice leads to progressive development of skin neoplasias associated with intrinsic NF-kappaB activation. PMID: 18809907
    6. Acute knockdown of delta-catenin leads to increases in spine and synapse density in hippocampal neurons during development. PMID: 19403811

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  • 亚细胞定位：
    Nucleus. Cell junction, adherens junction. Cell projection, dendrite. Perikaryon.
  • 蛋白家族：
    Beta-catenin family
  • 组织特异性：
    Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions.
  • 数据库链接：

    KEGG: mmu:18163

    STRING: 10090.ENSMUSP00000080427

    UniGene: Mm.321648

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