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  4. Recombinant Mouse Catenin delta-1 (Ctnnd1), partial

Recombinant Mouse Catenin delta-1 (Ctnnd1), partial

  • 中文名称：
    Recombinant Mouse Catenin delta-1(Ctnnd1) ,partial
  • 货号：
    CSB-YP006172MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-1(Ctnnd1) ,partial
  • 货号：
    CSB-EP006172MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-1(Ctnnd1) ,partial
  • 货号：
    CSB-EP006172MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-1(Ctnnd1) ,partial
  • 货号：
    CSB-BP006172MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin delta-1(Ctnnd1) ,partial
  • 货号：
    CSB-MP006172MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ctnnd1
  • Uniprot No.：
    P30999
  • 别名：
    Ctnnd1; Catns; Kiaa0384; Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas)
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
  • 基因功能参考文献：
    1. over-expression of P120-catenin suppressed NF-kappaB signaling and reversed the inflammatory effects. P120-catenin prevents endplate chondrocytes from undergoing ICMT-mediated inflammation by suppressing the expression of NF-kappaB. PMID: 28464387
    2. p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia. PMID: 27032419
    3. We conclude that p120ctn is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment PMID: 27556156
    4. p120 is required for dietary calcium suppression of oral carcinogenesis. PMID: 27682597
    5. p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth. PMID: 27769530
    6. a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported. PMID: 25713299
    7. Delta-catenin activates Rac1 and Cdc42 but inhibits RhoA in lymphatic endothelial cells. PMID: 25635825
    8. p120-catenin regulates REST and CoREST and modulates mouse embryonic stem cell differentiation. PMID: 25074806
    9. Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis. PMID: 25523391
    10. p120 functions as a differential regulator of TLR4 signaling pathways by facilitating TLR4 endocytic trafficking in macrophages, and support a novel role for p120 in influencing the macrophages in the lung inflammatory response to endotoxin. PMID: 25015829
    11. Shroom3 has a role in apical constriction during lens pit morphogenesis and is recruited in a pathway involving p120-catenin PMID: 25038041
    12. The recruitment of M-cadherin to lipid rafts during pre-fusion myogenesis events depended on interaction with p120 catenin, whereas the organization of microrafts was controlled by a small G protein, Rac1. PMID: 23978243
    13. ZBTB33 expression may elicit intestinal inflammation by antagonizing p120ctn function. PMID: 24040197
    14. delta-catenin plays a key role in molecular processes underlying learning and memory: dynamic palmitoylation of delta-catenin can coordinate activity-dependent changes in synapse adhesion and structure and the efficacy of synaptic transmission. PMID: 24562000
    15. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium. PMID: 23887639
    16. we show that somatic loss of p120-catenin (p120) in a conditional mouse model of noninvasive mammary carcinoma results in formation of stromal-dense tumors that resemble human metaplastic breast cancer and metastasize to lungs and lymph nodes PMID: 23733751
    17. mXinalpha directly interacts with p120-catenin and suppresses the p120-catenin-induced branching phenotype. PMID: 23296090
    18. Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex. PMID: 23481397
    19. Data indicate that PKCalpha phosphorylation of p120-catenin at S879 is a critical phospho-switch mediating disassociation of p120 from VE-cadherin that results in adherens junctions (AJ) disassembly. PMID: 22798526
    20. Activation of E-cadherin induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain. PMID: 22513089
    21. RPTPmu tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation. PMID: 21998202
    22. Findings reveal an essential role for p120 in mammary morphogenesis. PMID: 22461563
    23. Results indicate that the vertebrate planar cell polarity pathway regulates cochlear convergent extension (CE) and hair cell polarity independently and that a p120-catenin-dependent mechanism regulates CE of the cochlea. PMID: 22318628
    24. p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance PMID: 21747168
    25. p120-catenin plays critical protective role in cyclic stretch-induced alveolar barrier dysfunction. Maintenance of p120-catenin expression may be novel therapeutic strategy for prevention and treatment of ventilator-induced lung injury. PMID: 21571907
    26. Limited p120 ablation can promote tumorigenesis by an indirect non-cell autonomous mechanism. PMID: 21611205
    27. p120ctn is required for early tubule and glomerular morphogenesis, as well as control of luminal diameter, probably through regulation of cadherins. PMID: 21521738
    28. report herein that p120ctn loss leads to tumor development in mice PMID: 21481789
    29. p120-mediated inhibition of Toll-like receptor (TLR)4 signaling represents an important innate immune mechanism capable of regulating the lung host defense function. PMID: 21278343
    30. p120 stabilized ameloblast intercellular interactions during the secretory stage of dental enamel development. PMID: 20862276
    31. Results suggest that p120 acts as an obligate intermediate between ErbB2 and Rac1/Cdc42 to modulate the metastatic potential of breast cancer cells. PMID: 20595387
    32. The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin PMID: 20395297
    33. Reveal a fundamental role for p120 in regulating endothelial cadherin levels during vascular development. Loss of endothelial p120 results in lethality attributable to decreased microvascular density and hemorrhages. PMID: 20110533
    34. binding of p120ctn to microtubules is inversely related to its ability to regulate Rho GTPases PMID: 14660598
    35. cytoplasmic p120 can associate both directly and indirectly with the microtubule network, and p120 traffics along microtubules toward their plus ends PMID: 14676216
    36. epigenetic choice of active allele is clonally stable and that biallelic clones express p120 at twice the level of monoallelic clones PMID: 15522875
    37. p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis. PMID: 15543138
    38. development and show that p120 ablation by itself induces effects consistent with a role in tumor progression. PMID: 16399075
    39. p120 null epidermal cells activate nuclear NFkB, triggering a cascade of proinflammatory NFkB targets. PMID: 16469707
    40. p120 catenin plays an important role in maintaining the basal tone of membrane protein trafficking in adipocytes through the dual regulation of Rho and Rac function. PMID: 16754687
    41. Thus, p120ctn acts as a signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during spine and synapse development. PMID: 16815331
    42. Rac activation links diverse signaling systems to adherens junction assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho. PMID: 17129786
    43. p120ctn is necessary in the myelinating Schwann cell for the formation of mature adherens junctions and a normal myelin sheath PMID: 17382558
    44. P120 has the ability to regulate microtubule dynamics and affects cell motility independently of the cadherin adhesion system. PMID: 17584295
    45. Transfected delta-catenin T454A reduced the length and number of mature mushroom shaped spines in rat primary hippocampal neurons. PMID: 17993462
    46. the novel function of the p120 C-terminal region in regulating the trafficking of cytoplasmic E-cadherin PMID: 18159125
    47. both E-cadherin and p120 are important regulators of tumor cell growth and imply roles for both proteins in chemoresistance and targeted therapeutics. PMID: 19015320
    48. In Drosophila, The Neurons expressing H134R-ChR2 show enhanced responses to blue light pulses and less spike frequency adaptation than neurons expressing ChR2. PMID: 19339465
    49. GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis PMID: 19706605

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  • 亚细胞定位：
    Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane.; [Isoform 2]: Nucleus.
  • 蛋白家族：
    Beta-catenin family
  • 数据库链接：

    KEGG: mmu:12388

    STRING: 10090.ENSMUSP00000064518

    UniGene: Mm.35738

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