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  4. Recombinant Mouse Catenin alpha-2 (Ctnna2), partial

Recombinant Mouse Catenin alpha-2 (Ctnna2), partial

  • 中文名称：
    Recombinant Mouse Catenin alpha-2(Ctnna2) ,partial
  • 货号：
    CSB-YP717208MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin alpha-2(Ctnna2) ,partial
  • 货号：
    CSB-EP717208MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin alpha-2(Ctnna2) ,partial
  • 货号：
    CSB-EP717208MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin alpha-2(Ctnna2) ,partial
  • 货号：
    CSB-BP717208MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Catenin alpha-2(Ctnna2) ,partial
  • 货号：
    CSB-MP717208MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ctnna2
  • Uniprot No.：
    Q61301
  • 别名：
    Ctnna2; Catna2; Catenin alpha-2; Alpha N-catenin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
  • 基因功能参考文献：
    1. CDF mutation disrupts the positioning of many, but not all, Purkinje cells during development. PMID: 11835672
    2. A deletion in this protein causes cerebellar and hippocampal lamination defects and impaired startle reaction. PMID: 12089526
    3. Alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. PMID: 15034585
    4. alphaN-catenin expression is low in the ventricular zone and high in the developing cortical plate. PMID: 16457793
    5. has diverse roles in the organization of the central nervous system, but only in limited portions of the brain PMID: 16691566
    6. alpha-catenin has dual roles in intestinal tumorigenesis, a supporting role in tumor initiation, and a suppressive role in tumor progression PMID: 17989230

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell projection, axon. Nucleus.
  • 蛋白家族：
    Vinculin/alpha-catenin family
  • 组织特异性：
    Expressed almost exclusively in the nervous system.
  • 数据库链接：

    KEGG: mmu:12386

    STRING: 10090.ENSMUSP00000124376

    UniGene: Mm.34637

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