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  4. Recombinant Mouse Canalicular multispecific organic anion transporter 2 (Abcc3), partial

Recombinant Mouse Canalicular multispecific organic anion transporter 2 (Abcc3), partial

  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-YP001062MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-EP001062MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-EP001062MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-BP001062MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 2(Abcc3) ,partial
  • 货号：
    CSB-MP001062MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcc3
  • Uniprot No.：
    B2RX12
  • 别名：
    Abcc3; Cmoat2; Mrp3; Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; Multidrug resistance-associated protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.
  • 基因功能参考文献：
    1. Abbcc3 knock-out mice have enhanced platelet response to clopidogrel due to increased formation of clopidogral active metabolite. PMID: 27525577
    2. data show that this transporter activity is involved in ABCC3-induced senescence, demonstrating that this protein has a complex role in cancer, since its loss of function may promote escape from OIS and tumor formation PMID: 26073088
    3. Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively. PMID: 22166395
    4. role of the bile acid membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut, in the hepatic growth response elicited by bile acids and in liver regeneration after partial hepatectomy PMID: 21756856
    5. Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX. PMID: 21841039
    6. InsP(3)R2-mediated Ca(2+) signals enhance organic anion secretion into bile by targeting Mrp2 to the canalicular membrane. PMID: 20578149
    7. Data show that Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX. PMID: 19996279
    8. These results suggest that Mrp3 plays major roles in the efflux transport of various glucuronide conjugates from the enterocytes to the portal blood in the small intestine together with unknown transporter(s) PMID: 19889793
    9. induction of Mrp3 plays a significant role in hepatocyte protection during obstructive cholestasis PMID: 12837754
    10. VDR has a role in the protection of colon cells from bile acid toxicity through regulation of the Mrp3 expression PMID: 15824121
    11. Mrp3 does not have a major role in bile salt physiology, but is involved in the transport of glucuronidated compounds, which could include glucuronidated bile salts in humans PMID: 16225954
    12. Basolateral excretion of acetaminophen-glucuronide is nearly completely dependent on the function of Mrp3. Altered disposition in Mrp3-/- mice is associated with reduced hepatotoxicity. PMID: 16250050
    13. Radixin knockout increases Mrp3 expression. PMID: 17204408
    14. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 are reviewed. PMID: 17273943
    15. Mrp2 and Mrp3 provide alternative routes for the excretion of a glucuronidated substrate from the liver in vivo. PMID: 17485564
    16. Abcc6/3(-/-) double knock-out mice exhibited connective tissue mineralization similar to that in Abcc6 (-/-) mice. PMID: 17845218
    17. The lithogenic diet induced biliary hyperplasia and reduced bile salt transporter ABCC3 expression in C57L mice. PMID: 18717763
    18. Abcc3 transports MTX and 7OH-MTX back from the liver into the circulation, leading to increased plasma levels and urinary excretion. PMID: 19088030
    19. Complex pharmacokinetic behavior of ezetimibe depends on intestinal abcc2, abcc3, and abcg2. PMID: 19443695
    20. Report Role of hepatic Mrp3 transporter in prevention of bile acid toxicity after partial hepatectomy in mice. PMID: 19497955

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 组织特异性：
    Detected throughout the gastrointestinal tract, liver, lung, pancreas, bladder, gall bladder and at low levels in the adrenal gland.
  • 数据库链接：

    KEGG: mmu:76408

    STRING: 10090.ENSMUSP00000021231

    UniGene: Mm.23942

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