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  4. Recombinant Mouse Canalicular multispecific organic anion transporter 1 (Abcc2), partial

Recombinant Mouse Canalicular multispecific organic anion transporter 1 (Abcc2), partial

  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-YP840876MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-EP840876MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-EP840876MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-BP840876MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Canalicular multispecific organic anion transporter 1(Abcc2) ,partial
  • 货号：
    CSB-MP840876MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcc2
  • Uniprot No.：
    Q8VI47
  • 别名：
    Abcc2; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2; EC 7.6.2.2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors.
  • 基因功能参考文献：
    1. The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity. PMID: 29976647
    2. Circadian oscillation of Mrp2 protein expression was clearly observed in the mouse liver with levels down at the light phase and up at the dark phase. PMID: 28479363
    3. Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog. PMID: 24641901
    4. In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice. PMID: 24334255
    5. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in metallothionein-null cells. PMID: 22914987
    6. hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis PMID: 23125159
    7. Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX. PMID: 21841039
    8. hyperosmotic cholestasis is triggered by a NADPH oxidase-driven reactive oxygen species formation that mediates Fyn-dependent retrieval of the Mrp2 and Bsep from the canalicular membrane, which may involve an increased cortactin phosphorylation. PMID: 22057277
    9. Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan PMID: 21674030
    10. In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism. PMID: 21451505
    11. Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic. PMID: 20584751
    12. NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow PMID: 20404332
    13. Mrp2 mediates the adenosine triphosphate-dependent transport of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine but not S-(1,2-dichlorovinyl)-l-cysteine (DCVC) and may be involved in renal secretion of Ac-DCVC. PMID: 20060011
    14. Data show that Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX. PMID: 19996279
    15. Mrp2 transcription is down-regulated by Y-box protein 1. PMID: 12963034
    16. mutation in the canalicular mdr2 is an important factor during the development of progressive familial cholestasis PMID: 12967592
    17. nuclear factor, erythroid derived 2, like 2 appears to regulate Mrp2 gene expression via an antioxidant-response element element located at the proximal region of its promoter in response to exposure to xenobiotics PMID: 16426233
    18. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 are reviewed. PMID: 17273943
    19. Mrp2 and Mrp3 provide alternative routes for the excretion of a glucuronidated substrate from the liver in vivo. PMID: 17485564
    20. This decrease was not due to reduced cellular DMP uptake, as shown by normal expression of Oatp1b2 in livers of TR(-) rats and functional DMP uptake into isolated TR(-) rat hepatocytes. PMID: 17707334
    21. There are important species differences in the transport efficiency of MRP2 substrates and in the modulation of transport by other compounds that should be taken into account, when results obtained in mice are extrapolated to humans. PMID: 18180270
    22. Like Mrp2, GSTpi protein expression increased with pregnane X receptor activation PMID: 18349876
    23. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. PMID: 19017997
    24. Abcc2 is important for (biliary) excretion of MTX and its toxic metabolite 7OH-MTX. PMID: 19088030
    25. membrane cholesterol content is a critical determinant of ABCB11/ABCC2 transport activity, which might provide an explanation for the etiology of ATP8B1 disease PMID: 19228692
    26. Complex pharmacokinetic behavior of ezetimibe depends on intestinal abcc2, abcc3, and abcg2. PMID: 19443695

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 组织特异性：
    Expressed in liver.
  • 数据库链接：

    KEGG: mmu:12780

    STRING: 10090.ENSMUSP00000026208

    UniGene: Mm.39054

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