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  4. Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1 (Celsr1), partial

Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1 (Celsr1), partial

  • 中文名称：
    Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1(Celsr1) ,partial
  • 货号：
    CSB-YP005200MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1(Celsr1) ,partial
  • 货号：
    CSB-EP005200MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1(Celsr1) ,partial
  • 货号：
    CSB-EP005200MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1(Celsr1) ,partial
  • 货号：
    CSB-BP005200MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin EGF LAG seven-pass G-type receptor 1(Celsr1) ,partial
  • 货号：
    CSB-MP005200MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Celsr1
  • Uniprot No.：
    O35161
  • 别名：
    Celsr1Cadherin EGF LAG seven-pass G-type receptor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor that may have an important role in cell/cell signaling during nervous system formation.
  • 基因功能参考文献：
    1. type II spiral ganglion neurons make a distinctive 90 degrees turn towards the cochlear base to synapse with 10-15 outer hair cells. this axon turning event requires planar cell polarity signaling and is disrupted in Vangl2 and Celsr1 knockout mice. PMID: 29784671
    2. required for ureteric tree growth in early development PMID: 27597235
    3. Planar cell polarity phenotype is the cellular basis of the circling behavior in Celsr1 mutants. PMID: 28159525
    4. Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct. PMID: 25406397
    5. the second signal, governed by Celsr1, Fzd3, and Vangl2, coordinates polarity between cells in both radial progenitors and ependymal cells (tissue polarity). PMID: 25024228
    6. Data describe a novel distribution of Celsr1 protein to the basal surface of neuroepithelial cells within both the early neural tube and a less well-defined group of ventricular zone cells at the midline of the developing spinal cord. PMID: 20353824
    7. Developmental expression profiles of Celsr (Flamingo) genes in the mouse PMID: 11850187
    8. Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development PMID: 11891983
    9. Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. PMID: 19357712

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 组织特异性：
    Expressed in the brain, where it is localized principally in the ependymal cell layer, choroid plexus and the area postrema. Also found in spinal chord and in the eye.
  • 数据库链接：

    KEGG: mmu:12614

    STRING: 10090.ENSMUSP00000016172

    UniGene: Mm.22680

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