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  4. Recombinant Mouse Cadherin-23 (Cdh23), partial

Recombinant Mouse Cadherin-23 (Cdh23), partial

  • 中文名称：
    Recombinant Mouse Cadherin-23(Cdh23) ,partial
  • 货号：
    CSB-YP860841MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-23(Cdh23) ,partial
  • 货号：
    CSB-EP860841MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-23(Cdh23) ,partial
  • 货号：
    CSB-EP860841MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-23(Cdh23) ,partial
  • 货号：
    CSB-BP860841MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cadherin-23(Cdh23) ,partial
  • 货号：
    CSB-MP860841MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdh23
  • Uniprot No.：
    Q99PF4
  • 别名：
    Cdh23; Cadherin-23; Otocadherin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
  • 基因功能参考文献：
    1. The results illustrate the large effects that the mouse strain background and congenic regions have on the hearing loss associated with Cdh23 alleles. PMID: 28287619
    2. Many GABAergic interneurons, from their generation in the medial ganglionic eminence up to their settlement in the auditory cortex, express two cadherin-related (cdhr) proteins, cdhr23 and cdhr15, that form the hair bundle tip links gating the mechanoelectrical transduction channels. PMID: 28705869
    3. data suggest that CDH23-C is a CAMSAP3/Marshalin-binding protein that can modify MT networks indirectly through its interaction with CAMSAP3/Marshalin. PMID: 27349180
    4. interactions of wild type (WT) and mutant variants of N-terminal fragments (EC1+2) of cadherin-23 and protocadherin-15, two proteins essential for inner-ear mechanotransduction, are reported. PMID: 29261728
    5. It affects inner ear structures and results in age-related hearing loss. PMID: 27255811
    6. These results clearly show that the development of early-onset progressive hearing loss (ePHL) requires at least two mutant alleles of the Ush1g and Cdh23 genes. Our results also suggest that because the SANS and CDH23 proteins form a complex in the stereocilia, the interaction between these proteins may play key roles in the maintenance of stereocilia and the prevention of ePHL. PMID: 26936824
    7. Our results showed that systemic treatment with TUDCA significantly alleviated hearing loss and suppressed hair cell death in erl(Cdh23) mice. Additionally. PMID: 26748055
    8. This study further resolves the interaction between Atp2b2 and Cdh23 in a gene dosage and frequency-dependent manner, and finds that low auditory frequencies are significantly affected by the interaction. PMID: 23792079
    9. It plays an important role in the maintenence of tip links of stereocilia during the aging process. PMID: 24172198
    10. crystallography, molecular dynamics simulations and binding experiments to characterize the protocadherin 15-cadherin 23 bond PMID: 23135401
    11. A point mutation in the Cdh23 gene (208T>C) of C57BL/6J mice results in hearing loss around 1 month after birth. PMID: 20644563
    12. the Cdh23(nmf308/nmf308) mice with progressive hair cell loss had specific morphological changes and suffered a base to apex gradient and age-related hearing loss (AHL), and that mutations in cdh23 were linked to AHL PMID: 22326520
    13. A novel synaptic Usher complex comprised of clarin-1 and specific isoforms of CDH23, PCDH15 and VLGR1, was identified. PMID: 22363448
    14. Although Cdh23(ahl) homozygosity is necessary, it is not by itself sufficient to account for the accelerated hearing loss of C57BL/6J mice. PMID: 22138310
    15. ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice PMID: 21689626
    16. results therefore provide genetic evidence consistent with PCDH15 and CDH23 being part of the tip-link complex and necessary for normal mechanotransduction PMID: 21532990
    17. Cadherin-23, myosin VIIa and harmonin form a ternary complex and interact with phospholipids. PMID: 20639393
    18. Mice homozygous for Cdh23 gene mutations exhibit progressive hearing loss. PMID: 20470874
    19. Functional interaction of cadherin-23 with protocadherin-15 is required for the development of sensory transduction in auditory hair cells. PMID: 20739546
    20. Crystal structures of the first and second extracellular cadherin repeats of cadherin-23 are presented. Structures show typical cadherin folds with an elongated N terminus that precludes classical cadherin interactions. PMID: 20399731
    21. Cdh23 and Myo7a are both required for establishing and/or maintaining the proper organisation of the stereocilia bundle and that they do not genetically interact to affect this process nor to cause age-related hearing loss. PMID: 12121736
    22. forms a complex with harmonin by means of PDZ-domain interactions PMID: 12407180
    23. the shaping of the hair bundle relies on a functional unit composed of myosin VIIa, harmonin b and cadherin 23 that is essential to ensure the cohesion of the stereocilia PMID: 12485990
    24. a synonymous single-nucleotide polymorphism in exon 7 of Cdh23 that shows significant association with AHL and the deafness modifier mdfw (modifer of deafwaddler) PMID: 12910270
    25. noise-induced hearing loss in 11-12-week-old Cdh23(v) heterozygotes is two times greater than for wild-type littermates. PMID: 14648237
    26. CDH23 forms a complex with myosin-1c, the only known component of the mechanotransduction apparatus, suggesting that CDH23 and myosin-1c cooperate to regulate the activity of mechanically gated ion channels in hair cells PMID: 15057245
    27. CDH23 and PCDH15 play an essential long-term role in maintaining the normal organization of the stereocilia bundle. PMID: 15537665
    28. Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells PMID: 15882573
    29. Cdh23 participation in stereocilia links may be restricted to developing hair bundles PMID: 15882574
    30. cadherin 23 localizes to stereocilia during hair bundle development in late gestation and early postnatal days PMID: 16005171
    31. The present results thus suggest different fates of CDH23/Cdh23 with mutations affecting the cytoplasmic region. PMID: 16281288
    32. Myosin-1c receptors and cadherin 23 interact at the tips of hair-cell stereocilia; this interaction is modulated by calmodulin. PMID: 17050716
    33. Biochemical experiments show that CDH23 homodimers interact in trans with PCDH15 homodimers to form a filament with structural similarity to tip links PMID: 17805295
    34. We have genetically mapped a locus (ahl4),a strain-specific Cdh23 dimorphism, on distal Chr 10 that is a significant contributor to the early onset age-related hearing loss of A/J mice. PMID: 18280008
    35. ahl8 is a major contributor to the hearing loss of DBA/2J mice and that its effects are dependent on the predisposing Cdh23 ahl genotype of this strain. PMID: 18662770
    36. We detect tip link-like links in mouse mutants with null alleles of Cdh23, suggesting the presence of other components that permit formation of a link between the tip of one stereocilium and the side of the adjacent taller stereocilium. PMID: 18996172
    37. CDH23 null alleles cause deaf-blindness (Usher syndrome type 1D; USH1D), whereas missense mutations cause nonsyndromic deafness (DFNB12). PMID: 19270079
    38. REVIEW: role of CDH23 in mature hearing PMID: 19321743
    39. EHD4 is a novel CDH23-interacting protein that could regulate CDH23 trafficking/localization in a calcium-sensitive manner. PMID: 19487694
    40. The time- and tissue-dependent expression patterns that we have shown for Cdh23 alternative transcripts suggest developmental roles and tissue-specific functions for the various transcripts. PMID: 19756182

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  • 相关疾病：
    Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    In adult animals relatively high levels of expression are found in testis, skeletal muscle, heart, eye and thymus, and lower expression in kidney, lung and brain. Found in the sensory hair cells of the inner ear.
  • 数据库链接：

    KEGG: mmu:22295

    STRING: 10090.ENSMUSP00000101104

    UniGene: Mm.440327

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