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  4. Recombinant Mouse CD2-associated protein (Cd2ap)

Recombinant Mouse CD2-associated protein (Cd2ap)

  • 中文名称：
    Recombinant Mouse CD2-associated protein(Cd2ap)
  • 货号：
    CSB-YP004914MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CD2-associated protein(Cd2ap)
  • 货号：
    CSB-EP004914MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CD2-associated protein(Cd2ap)
  • 货号：
    CSB-EP004914MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CD2-associated protein(Cd2ap)
  • 货号：
    CSB-BP004914MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CD2-associated protein(Cd2ap)
  • 货号：
    CSB-MP004914MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cd2ap
  • Uniprot No.：
    Q9JLQ0
  • 别名：
    Cd2ap; Mets1; CD2-associated protein; Mesenchyme-to-epithelium transition protein with SH3 domains 1; METS-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-637
  • 氨基酸序列
    MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE TEPKDDNLPI KRERQGNVAS LVQRISTYGL PAGGIQPHPQ TKAIKKKTKK RQCKVLFDYS PQNEDELELI VGDVIDVIEE VEEGWWSGTL NNKLGLFPSN FVKELESTED GETHNAQEES EVPLTGPTSP LPSPGNGSEP APGSVAQPKK IRGIGFGDIF KEGSVKLRTR TSSSETEEKK TEKPLILQPL GSRTQNVEVT KPDVDGKIKA KEYCRTLFPY TGTNEDELTF REGEIIHLIS KETGEAGWWK GELNGKEGVF PDNFAVQISE LDKDFPKPKK PPPPAKGPAP KPDLSAAEKK AFPLKAEEKD EKSLLEQKPS KPAAPQVPPK KPTAPTKASN LLRSPGAVYP KRPEKPVPPP PPAAKINGEV SIISSKIDTE PVSKPKLDPE QLPVRPKSVD LDAFVARNSK ETDDVNFDDI ASSENLLHLT ANRPKMPGRR LPGRFNGGHS PTQSPEKTLK LPKEDDSGNL KPLEFKKDAS YSSKSSLSTP SSASKVNTAA FLTPLELKAK AEADDGKRNS VDELRAQIIE LLCIVDALKK DHGKELEKLR KELEEEKAMR SNLEVEIAKL KKAVLLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation.
  • 基因功能参考文献：
    1. Ang II induces the relocalization and reduction of CD2AP via AT1R, which would cause podocyte apoptosis by the suppression of CD2AP/PI3-K signaling PMID: 27590856
    2. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP. PMID: 27441654
    3. Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta in neurons increasing the risk for late-onset AD. PMID: 27895104
    4. CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process. PMID: 26546360
    5. CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting PMID: 27076424
    6. CD2AP has role in mediating blood-brain barrier integrity and cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk. PMID: 26358779
    7. CD2-Associated Protein affects Abeta levels and Abeta42/Abeta40 ratio in vitro PMID: 25887956
    8. only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51 PMID: 24425877
    9. CD2AP is not involved in the regulation of type I IFNs in plasmacytoid dendritic cells. Its major function is on the actin cytoskeleton, affecting migration to local lymph nodes under conditions of inflammation. PMID: 24218450
    10. CD2AP deficiency results in the excretion of intact albumin in knockout mice. PMID: 24140342
    11. the formation of lamellipodia is mediated by a complex of cortactin, CD2AP, and actin capping protein PMID: 23090967
    12. These data descrived the importance of concomitant decreases in podocin, CD2AP and tensin2 during septic acute renal failure-associated proteinuria. PMID: 21799297
    13. Sh3kbp1 is SUMOylated by SUMO-1, -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap. PMID: 22203040
    14. identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease PMID: 21911934
    15. Coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L). PMID: 20457601
    16. CD2AP is expressed in glomerular podocytes, and may play a role in a specialized adhesion complex known as the slit diaphragm. PMID: 11733379
    17. Cd2ap is involved in the regulation of the actin cytoskeleton and may act as a direct adapter between the actin cytoskeleton and cell membrane proteins PMID: 12217865
    18. mice with CD2AP haploinsufficiency developed glomerular changes at 9 months of age and had increased susceptibility to glomerular injury by nephrotoxic antibodies or immune complexes PMID: 12764198
    19. CD2-associated protein has a role in transforming growth factor-beta-induced apoptosis PMID: 15213232
    20. CD2AP associated with dynamic actin in specific late endosomal compartment in podocytes, suggesting CD2AP might be crucially involved in endosomal sorting and/or trafficking via regulation of actin assembly on vesicles PMID: 15956777
    21. The abnormality of a single podocyte molecule, caused by a single gene mutation in alpha Cd2ap can lead to hereditary nephrotic syndromes. PMID: 16501493
    22. CD2AP, Fyn, and synaptopodin have roles in development of focal segmental glomerulosclerosis in a mouse model PMID: 16628251
    23. role of CD2AP/CIN85 protein balance in the normal signaling response of podocytes. PMID: 17213204
    24. Distinct up- & downregulation of CD2AP occurred in various cell types at different stages of early development & organogenesis. It has various interaction partners in regulatory pathways for signaling, cytoskeletal arrangement & vesicular trafficking. PMID: 18177421
    25. CD2-associated protein may play a crucial role in maintaining the normal function of podocytes and lowered CD2-associated protein causes podocyte injury by disrupting the cytoskeleton and disturbing the nephrin-CD2AP signaling pathway. PMID: 19306938
    26. TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes. PMID: 19679673

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell junction.
  • 组织特异性：
    Expressed in podocytes (at protein level).
  • 数据库链接：

    KEGG: mmu:12488

    STRING: 10090.ENSMUSP00000024709

    UniGene: Mm.218637

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