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  4. Recombinant Mouse CAP-Gly domain-containing linker protein 1 (Clip1), partial

Recombinant Mouse CAP-Gly domain-containing linker protein 1 (Clip1), partial

  • 中文名称：
    Recombinant Mouse CAP-Gly domain-containing linker protein 1(Clip1) ,partial
  • 货号：
    CSB-YP838749MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CAP-Gly domain-containing linker protein 1(Clip1) ,partial
  • 货号：
    CSB-EP838749MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CAP-Gly domain-containing linker protein 1(Clip1) ,partial
  • 货号：
    CSB-EP838749MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CAP-Gly domain-containing linker protein 1(Clip1) ,partial
  • 货号：
    CSB-BP838749MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CAP-Gly domain-containing linker protein 1(Clip1) ,partial
  • 货号：
    CSB-MP838749MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clip1
  • Uniprot No.：
    Q922J3
  • 别名：
    Clip1; Kiaa4046; RsnCAP-Gly domain-containing linker protein 1; Cytoplasmic linker protein 170; CLIP-170; Restin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
  • 基因功能参考文献：
    1. we report an unexpected finding that CLIP170 negatively regulates TLR4 signaling by the targeted ubiquitination and degradation of TIRAP. Furthermore, we observed that CLIP170 expression is modulated by LPS to maintain the cellular homeostasis. PMID: 29222167
    2. Drosophila CLIP-190 (and potentially also mouse CLIP-170) does not possess a significant role in the axon growth-promoting microtubule machinery. PMID: 25694447
    3. Cytoplasmic linker protein 170 was ubiquitously expressed in mouse kidney, liver, lung, normal non-atherosclerotic aorta, and atherosclerotic aorta and was partly localized in the vascular endothelium. PMID: 24530770
    4. Phosphorylation regulates CLIP-170 conformational changes resulting in its autoinhibition. PMID: 20519438
    5. Restin expressed in vivo suppresses the growth of tumors in nude mice PMID: 12198558
    6. CLIP170 is a key regulator of microtubule stabilization that is required for enhanced cell spreading and phagocytosis in activated macrophages. PMID: 17785815
    7. Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends. PMID: 18283108

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle.
  • 数据库链接：

    KEGG: mmu:56430

    STRING: 10090.ENSMUSP00000107192

    UniGene: Mm.241109

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