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  4. Recombinant Mouse Brother of CDO (Boc), partial

Recombinant Mouse Brother of CDO (Boc), partial

  • 中文名称：
    Recombinant Mouse Brother of CDO(Boc) ,partial
  • 货号：
    CSB-YP728127MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Brother of CDO(Boc) ,partial
  • 货号：
    CSB-EP728127MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Brother of CDO(Boc) ,partial
  • 货号：
    CSB-EP728127MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Brother of CDO(Boc) ,partial
  • 货号：
    CSB-BP728127MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Brother of CDO(Boc) ,partial
  • 货号：
    CSB-MP728127MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Boc
  • Uniprot No.：
    Q6AZB0
  • 别名：
    BocBrother of CDO; Protein BOC
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
  • 基因功能参考文献：
    1. Findings provide evidence for a dual requirement for Boc and Gas1 during early development of the palate, mediating cell cycle regulation during growth and subsequent fusion of the palatal shelves. PMID: 27811357
    2. BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth. PMID: 27871935
    3. Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc PMID: 25576054
    4. Elevated Boc levels induce proliferation of granule cell precursors in early medulloblastoma. PMID: 25263791
    5. The results of this study proposed that expression of Boc in cells from the ventrotemporal crescent of the retina is required to sustain Zic2 expression, likely by regulating the levels of Shh signaling from the nearby cRGCs. Zic2. PMID: 23678105
    6. Cdo;Boc double mutants on a largely Cdo-resistant genetic background have lobar holoprosencephaly. PMID: 21183473
    7. Genetic loss-of-function of GAS1, Cdon and BOC in SHH is associated with defective cell proliferation. PMID: 21664577
    8. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
    9. Expression of the boc gene during murine embryogenesis PMID: 11891987
    10. Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. PMID: 16647304
    11. data suggest that Boc is essential as a receptor for Shh in commissural axon guidance PMID: 17086203
    12. Boc expression increases in subcutaneous white adipose tissue and decreases in intra-abdominal epididymal white adipocytes in obese mice. PMID: 18721461

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Highly expressed in embryonic somites, limb buds, dermomyotomes and in the neural tube.
  • 数据库链接：

    KEGG: mmu:117606

    STRING: 10090.ENSMUSP00000023370

    UniGene: Mm.41561

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