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  4. Recombinant Mouse Branched-chain-amino-acid aminotransferase, cytosolic (Bcat1)

Recombinant Mouse Branched-chain-amino-acid aminotransferase, cytosolic (Bcat1)

  • 中文名称：
    Recombinant Mouse Branched-chain-amino-acid aminotransferase, cytosolic(Bcat1)
  • 货号：
    CSB-YP002600MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Branched-chain-amino-acid aminotransferase, cytosolic(Bcat1)
  • 货号：
    CSB-EP002600MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Branched-chain-amino-acid aminotransferase, cytosolic(Bcat1)
  • 货号：
    CSB-BP002600MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Branched-chain-amino-acid aminotransferase, cytosolic(Bcat1)
  • 货号：
    CSB-MP002600MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bcat1
  • Uniprot No.：
    P24288
  • 别名：
    Bcat1; Eca39Branched-chain-amino-acid aminotransferase; cytosolic; BCAT(c); EC 2.6.1.42; Protein ECA39
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-386
  • 氨基酸序列
    MKDCSNGCSA PFAGERGSEE VAETFRAKDL IITPATVLKE KPDPDSLVFG ATFTDHMLTV EWSSASGWEK PHIKPFGNLP IHPAASVLHY AVELFEGLKA FRGVDNKIRL FRPDLNMDRM CRSAVRTTLP MFDKEELLKC ILQLLQIDQE WVPYSTSASL YIRPTFIGTE PSLGVKKPSK ALLFVILSPV GPYFSSGSFT PVSLWANPKY IRAWKGGTGD CKMGGNYGAS LLAQCEAVEN GCQQVLWLYG KDNQITEVGT MNLFLYWINE DGEEELATPP LDGIILPGVT RQSILELAQQ WGEFKVCERH LTMDDLATAL EGNRVKEMFG SGTACVVCPV SDILYKGQML HIPTMENGPK LASRILGKLT DIQYGRVESD WTIELP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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Bcat1 Proteins

靶点详情

  • 功能：
    Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
  • 基因功能参考文献：
    1. regulatory role in macrophage function PMID: 28699638
    2. results suggest transcriptional adaptations occur in BCATm KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes PMID: 26351290
    3. BCATc as a novel regulator of T cell activation and metabolism PMID: 24847056
    4. leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 and BCKDK) that metabolize branched-chain amino acids. PMID: 24349566
    5. analysis of the biochemical mechanism of BCATm (branched-chain aminotransferase) catalysis of reversible transamination of leucine and alpha-ketoglutarate to KIC and glutamate PMID: 20736162
    6. Bcat1 is a candidate for the type I diabetes susceptibility locus Idd6 PMID: 14563018
    7. Bcat1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility. PMID: 15064703
    8. These results demonstrate that the expression of the BCATc gene in the brain is specifically regulated by BDNF in a time- and region-dependent fashion. PMID: 16828066
    9. BCATc mRNA gradually appears in different brain regions starting from early stages of neural development, and is maintained until adulthood. PMID: 17150414
    10. BCATm(-/-) mice had elevated plasma branched-chain amino acids & decreased adiposity & body weight, despite eating more food, along with increased energy expenditure, improvements in glucose & insulin tolerance & protection from diet-induced obesity PMID: 17767905

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class-IV pyridoxal-phosphate-dependent aminotransferase family
  • 组织特异性：
    Expressed in brain and kidney. Overexpressed in MYC-induced brain tumors, lymphomas, as well as in a teratocarcinoma cell line.
  • 数据库链接：

    KEGG: mmu:12035

    STRING: 10090.ENSMUSP00000032402

    UniGene: Mm.4606

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