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  4. Recombinant Mouse Beta,beta-carotene 15,15'-monooxygenase (Bcmo1)

Recombinant Mouse Beta,beta-carotene 15,15'-monooxygenase (Bcmo1)

  • 中文名称：
    Recombinant Mouse Beta,beta-carotene 15,15'-monooxygenase(Bcmo1)
  • 货号：
    CSB-YP878078MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta,beta-carotene 15,15'-monooxygenase(Bcmo1)
  • 货号：
    CSB-EP878078MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta,beta-carotene 15,15'-monooxygenase(Bcmo1)
  • 货号：
    CSB-EP878078MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Beta,beta-carotene 15,15'-monooxygenase(Bcmo1)
  • 货号：
    CSB-BP878078MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Beta,beta-carotene 15,15'-monooxygenase(Bcmo1)
  • 货号：
    CSB-MP878078MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bco1
  • Uniprot No.：
    Q9JJS6
  • 别名：
    Bco1; Bcdo; Bcdo1; Bcmo1; Beta,beta-carotene 15,15'-dioxygenase; EC 1.13.11.63; Beta-carotene dioxygenase 1; Beta-carotene oxygenase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-566
  • 氨基酸序列
    MEIIFGQNKK EQLEPVQAKV TGSIPAWLQG TLLRNGPGMH TVGESKYNHW FDGLALLHSF SIRDGEVFYR SKYLQSDTYI ANIEANRIVV SEFGTMAYPD PCKNIFSKAF SYLSHTIPDF TDNCLINIMK CGEDFYATTE TNYIRKIDPQ TLETLEKVDY RKYVAVNLAT SHPHYDEAGN VLNMGTSVVD KGRTKYVIFK IPATVPDSKK KGKSPVKHAE VFCSISSRSL LSPSYYHSFG VTENYVVFLE QPFKLDILKM ATAYMRGVSW ASCMSFDRED KTYIHIIDQR TRKPVPTKFY TDPMVVFHHV NAYEEDGCVL FDVIAYEDSS LYQLFYLANL NKDFEEKSRL TSVPTLRRFA VPLHVDKDAE VGSNLVKVSS TTATALKEKD GHVYCQPEVL YEGLELPRIN YAYNGKPYRY IFAAEVQWSP VPTKILKYDI LTKSSLKWSE ESCWPAEPLF VPTPGAKDED DGVILSAIVS TDPQKLPFLL ILDAKSFTEL ARASVDADMH LDLHGLFIPD ADWNAVKQTP AETQEVENSD HPTDPTAPEL SHSENDFTAG HGGSSL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.
  • 基因功能参考文献：
    1. This is the first demonstration that Bco1 disruption lowers murine circulating testosterone levels and thereby reduces prostatic androgen receptor signaling and prostatic cellular proliferation, further supporting the role of this protein in processes more diverse than carotenoid cleavage. PMID: 27629887
    2. tissue- and sex-specific effects of beta-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism PMID: 25602705
    3. BCO1 modulates heart metabolism and function, possibly by altering levels of cofactors required for the actions of nuclear hormone receptors PMID: 25260612
    4. Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, activated AMPKalpha2, potentiated mitophagy and mitochondrial biogenesis and enhanced lipid oxidation and secretion in the liver of mice. PMID: 24449471
    5. Pleiotropic actions of Carotene-15,15'-monooxygenase and carotene-9',10'-monooxygenase supporting a strong role of these proteins in regulating tissue carotenoid accumulation as well as tomato carotenoid-independent regulation of lipid metabolism. PMID: 24034573
    6. in addition to cleaving beta-carotene to generate retinoids, CMOI serves an additional function(s) in retinoid and lipid metabolism and point to its role in the formation of specific lipids, possibly for use in nervous system tissue. PMID: 23988655
    7. a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediate could provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production. PMID: 24106281
    8. beta-Carotene and its cleavage enzyme beta-carotene-15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues. PMID: 21285397
    9. Gene expression in lungs is changed in the opposite direction by beta-carotene in male and female Bcmo1 -/- mice. PMID: 20820853
    10. In Bcmo1-deficient mice, Fzd6 AND Cthrc1 genes are upregulated. PMID: 20472610
    11. Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene. PMID: 20372966
    12. The role of conserved catalytic site aromatic residues in the catalytic mechanism of BCMO1 is consistent with the formation of a substrate carbocation intermediate and cation-pi stabilization. PMID: 20003456
    13. Transcriptional activation of the beta-carotene 15, 15'-monooxygenase gene by peroxisome proliferator-activated receptor (beta-carotene 15, 15'-monooxygenase). PMID: 12759335
    14. elevation of beta-carotene 15,15'-dioxygenase activity in hairless mice after UV exposure may be a response to reduction of the skin retinoid concentration PMID: 12882399
    15. the conserved histidines and Glu405 are absolutely required for the catalytic mechanism of BCMO1 PMID: 15951442
    16. CMO1 is the key enzyme for vitamin A production in mice and alters lipid metabolism. PMID: 17855355
    17. Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine. PMID: 18093975
    18. CMO I KO mice fed low levels of vitamin A have altered lycopene biodistribution and isomer patterns and do not cleave beta-carotene to vitamin A at appreciable levels. PMID: 19022959
    19. Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene (BCMO-1) expression PMID: 19556237

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  • 蛋白家族：
    Carotenoid oxygenase family
  • 组织特异性：
    Expressed in liver, kidney, small intestine and testis.
  • 数据库链接：

    KEGG: mmu:63857

    STRING: 10090.ENSMUSP00000034308

    UniGene: Mm.174133

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