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  4. Recombinant Mouse Band 4.1-like protein 3 (Epb41l3), partial

Recombinant Mouse Band 4.1-like protein 3 (Epb41l3), partial

  • 中文名称：
    小鼠Epb41l3重组蛋白
  • 货号：
    CSB-YP895762MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Epb41l3重组蛋白
  • 货号：
    CSB-EP895762MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Epb41l3重组蛋白
  • 货号：
    CSB-EP895762MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Epb41l3重组蛋白
  • 货号：
    CSB-BP895762MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Epb41l3重组蛋白
  • 货号：
    CSB-MP895762MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Epb41l3
  • Uniprot No.：
    Q9WV92
  • 别名：
    Epb41l3; Dal1; Epb4.1l3; Kiaa0987Band 4.1-like protein 3; 4.1B; Differentially expressed in adenocarcinoma of the lung protein 1; DAL-1; DAL1P; mDAL-1) [Cleaved into: Band 4.1-like protein 3; N-terminally processed]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
  • 基因功能参考文献：
    1. This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6. PMID: 26496923
    2. findings document novel, isoform-selective roles for 130-kDa 4.1B in adhesion, spreading, and migration of MEF cells by affecting actin organization PMID: 24381168
    3. The results of this study demonstrated that 4.1B is a key cytoskeletal scaffold for axonal adhesion molecules expressed in the juxtaparanodal and internodal domains that unexpectedly regulates myelin sheath thickness. PMID: 23109359
    4. in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber. PMID: 21966409
    5. Protein 4.1B plays a key role in ensuring the proper molecular compartmentalization of hemi-node-type region of axons of motor neurons. PMID: 21958379
    6. 4.1B plays a pivotal role in interactions between the paranodal AGSJs and axonal cytoskeleton. PMID: 21632923
    7. 4.1B was specifically and constantly expressed in the stereocilia tips during postnatal development. PMID: 19853587
    8. Protein 4.1B is localized in islets of Langerhans and may have a role in phenotypic transition from pancreatic adenoma to carcinoma. PMID: 14574582
    9. protein 4.1B in mouse small intestine & DAL-1 in human colon showed similar distributions in normal intestinal epithelial cells; expression reduced in intestinal carcinoma; may function in preventing malignant transformation of intestinal epithelial cells PMID: 15517334
    10. 4.1B regulates mammary epithelial cell proliferation during pregnancy and suggest that its loss may influence mammary carcinoma pathogenesis PMID: 16007173
    11. 4.1B gene is not required for normal development and 4.1B/Dal-1 does not function as a tumor suppressor gene PMID: 16260618
    12. suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease PMID: 17640904
    13. We propose that the 4.1B-containing membrane skeleton may play a role in regulating the Na(+) and HCO(3)(-) reabsorption in S1-S2 proximal tubules. PMID: 17712176
    14. In this study, the expression of 4.1B and its interaction with tumor suppressor in lung cancer-1 were examined in rodent adrenal gland, and the involvement of 4.1B in tumorigenesis PMID: 19321127

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell junction. Note=Detected in the cytoplasm of actively dividing cells.
  • 组织特异性：
    Detected in brain (at protein level). Highest expression in brain, lower in testis, adrenal gland, heart and kidney. Also present in muscle and epithelial cells. Isoform 1 is expressed in brain, isoform 2 is expressed in heart and isoform 3 is mostly expr
  • 数据库链接：

    KEGG: mmu:13823

    STRING: 10090.ENSMUSP00000079098

    UniGene: Mm.131135

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