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  4. Recombinant Mouse BCL-6 corepressor (Bcor), partial

Recombinant Mouse BCL-6 corepressor (Bcor), partial

  • 中文名称：
    Recombinant Mouse BCL-6 corepressor(Bcor) ,partial
  • 货号：
    CSB-YP807023MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse BCL-6 corepressor(Bcor) ,partial
  • 货号：
    CSB-EP807023MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse BCL-6 corepressor(Bcor) ,partial
  • 货号：
    CSB-EP807023MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse BCL-6 corepressor(Bcor) ,partial
  • 货号：
    CSB-BP807023MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse BCL-6 corepressor(Bcor) ,partial
  • 货号：
    CSB-MP807023MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bcor
  • Uniprot No.：
    Q8CGN4
  • 别名：
    Bcor; Kiaa1575BCL-6 corepressor; BCoR
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
  • 基因功能参考文献：
    1. Genomic characterization of Emu-Myc mouse lymphomas identifies Bcor as a Myc cooperative tumor-suppressor gene. PMID: 28262675
    2. results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies PMID: 28827447
    3. Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin Signaling in trophoblast stem cells (TSCs). PMID: 26221038
    4. T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity. PMID: 25964495
    5. IRF8 pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity. PMID: 25331958
    6. Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development. PMID: 20563598
    7. Study isolated an Fbxl10/Jhdm1B complex by Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor PMID: 17296600
    8. Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development. PMID: 18795143

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BCOR family
  • 组织特异性：
    Expressed in heart, liver, lung, skeletal muscle, spleen and testis.
  • 数据库链接：

    KEGG: mmu:71458

    STRING: 10090.ENSMUSP00000111175

    UniGene: Mm.196328

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