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  4. Recombinant Mouse Anthrax toxin receptor 2 (Antxr2), partial

Recombinant Mouse Anthrax toxin receptor 2 (Antxr2), partial

  • 中文名称：
    Recombinant Mouse Anthrax toxin receptor 2(Antxr2),partial
  • 货号：
    CSB-YP001833MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Anthrax toxin receptor 2(Antxr2),partial
  • 货号：
    CSB-EP001833MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Anthrax toxin receptor 2(Antxr2),partial
  • 货号：
    CSB-EP001833MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Anthrax toxin receptor 2(Antxr2),partial
  • 货号：
    CSB-BP001833MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Anthrax toxin receptor 2(Antxr2),partial
  • 货号：
    CSB-MP001833MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Antxr2
  • Uniprot No.：
    Q6DFX2
  • 别名：
    Antxr2Anthrax toxin receptor 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Necessary for cellular interactions with laminin and the extracellular matrix.
  • 基因功能参考文献：
    1. Loss of Antxr2 promotes accumulation of collagen VI. Antxr2 is also associated with collagen VI signaling and degradation. PMID: 28604699
    2. blood pressure measured under anesthesia in Antxr2 siRNA-injected mice rose significantly compared with that of the controls, suggesting that ANTXR2 is a causative gene in the human 4q21 GWAS-blood pressure locus. PMID: 24739539
    3. Silencing CMG2 using targeted siRNAs provided almost complete protection against anthrax lethal toxin-induced cytotoxicity and death in murine and human macrophages. PMID: 24742682
    4. we have discovered that ANTXR1 and ANTXR2 function as positive regulators of MT1-MMP activity. PMID: 22529944
    5. these results demonstrate that CMG2 is not required for normal mouse embryonic development but is indispensable for murine parturition PMID: 22575514
    6. Data show that the two different PA oligomers are equally stabilized by ANTXR interactions. PMID: 21079738
    7. This work demonstrates that anthrax toxin uptake through CMG2 and the resulting impairment of myeloid cells are essential to anthrax infection. PMID: 21075356
    8. ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds. PMID: 19901963
    9. Cytoplasmic delivery of lethal factor by anthrax toxin receptor 2 was mediated by cathepsin B. PMID: 19858192
    10. because protective antigen binds to CMG2 with much higher affinity than it does to TEM8, a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway PMID: 16141341

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ATR family
  • 数据库链接：

    KEGG: mmu:71914

    STRING: 10090.ENSMUSP00000031281

    UniGene: Mm.24842

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