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  4. Recombinant Mouse Anoctamin-2 (Ano2), partial

Recombinant Mouse Anoctamin-2 (Ano2), partial

  • 中文名称：
    Recombinant Mouse Anoctamin-2(Ano2) ,partial
  • 货号：
    CSB-YP807016MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Anoctamin-2(Ano2) ,partial
  • 货号：
    CSB-EP807016MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Anoctamin-2(Ano2) ,partial
  • 货号：
    CSB-EP807016MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Anoctamin-2(Ano2) ,partial
  • 货号：
    CSB-BP807016MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Anoctamin-2(Ano2) ,partial
  • 货号：
    CSB-MP807016MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ano2
  • Uniprot No.：
    Q8CFW1
  • 别名：
    Ano2; Tmem16bAnoctamin-2; Transmembrane protein 16B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
  • 基因功能参考文献：
    1. Results of behavioral studies obtained from Ano2 (-/-) mice, a mouse line that was previously shown to lack this particular mode of ionic plasticity. The animals display motor coordination deficits that constitute a condition of mild ataxia. Moreover, motor learning is severely impaired in Ano2 (-/-) mice, suggesting cerebellar dysfunction. PMID: 28536821
    2. Results suggest that the anoctamin 2-mediated amplification mechanism enables mice to track weak, unfamiliar olfactory cues. PMID: 28784854
    3. TMEM16B controls AP firing and ensures correct glomerular targeting of olfactory sensory neurons s expressing I7. PMID: 27619419
    4. Loss of TMEM16B expression resulted in the absence of Calcium-activated Chloride channels in inferior Olive neurons, leading to markedly diminished action potential firing of IO neurons. TMEM16B knockout mice. Moreover, exhibited severe cerebellar motor learning deficits. PMID: 28858616
    5. The siRNA knock-down suggests that Ano2 contributes to Ca(2+)-dependent chloride conductance in the RPE. PMID: 27940219
    6. Ano6 and Ano2 proteins co-localize in the ciliary membrane microdomains.Thus, we provide evidence for interaction of ANO2 and ANO6 in olfactory cilia. PMID: 25500808
    7. Selective antagonism of ANO2 promotes relaxation of spontaneous myometrial contractions. It inhibits both agonist-induced and spontaneous transient inward currents and abolishes G-protein coupled receptor mediated elevations in intracellular calcium. PMID: 24928056
    8. Our results provide the first evidence that TMEM16B gating is modulated by permeant anions and provide the basis for future studies aimed at identifying the molecular determinants of TMEM16B ion selectivity and gating. PMID: 24863931
    9. TMEM16B calcium-activated chloride channels control action potential waveform and synaptic efficacy in hippocampal neurons. PMID: 22500639
    10. Data show that Ano2 is expressed in the main olfactory epithelium and in the vomeronasal organ, which also expresses the related Ano1 channel. PMID: 21516098
    11. TMEM16b/anoctamin2 is likely to be a major subunit of the native olfactory Ca(2+)-activated Cl(-) current. PMID: 20837642
    12. Tmem16b expression is highly specific for the OE, in contrast to the closely related Tmem16a, which shows a broad expression pattern in secretory epithelial cells. PMID: 20100788
    13. Data show the expression of Tmem16b during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems. PMID: 18729231
    14. TMEM16B is lost from photoreceptor membranes of MPP4-deficient mice PMID: 19474308
    15. Our results demonstrate that mTMEM16B functions as a Ca(2+)-activated Cl(-) channel when expressed in HEK 293T cells. PMID: 19475416
    16. ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. PMID: 19561302
    17. Ano2 likely amplifies the odor-induced generator potential in olfactory sensory neuron cilia by sensing elevated calcium levels, permitting the outward flow of chloride ions from the cell. PMID: 19561302

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anoctamin family
  • 组织特异性：
    Expressed in retina, especially in the photoreceptor synaptic terminals, and in olfactory epithelium, particularly in sensory neurons (OSNs) and cilia (at protein level). Also observed in retinal pigment epithelium (RPE), olfactory bulb, brain, and cortex
  • 数据库链接：

    KEGG: mmu:243634

    STRING: 10090.ENSMUSP00000125303

    UniGene: Mm.333398

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