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  4. Recombinant Mouse Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Asz1)

Recombinant Mouse Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Asz1)

  • 中文名称：
    Recombinant Mouse Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1(Asz1)
  • 货号：
    CSB-YP855329MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1(Asz1)
  • 货号：
    CSB-EP855329MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1(Asz1)
  • 货号：
    CSB-EP855329MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1(Asz1)
  • 货号：
    CSB-BP855329MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1(Asz1)
  • 货号：
    CSB-MP855329MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Asz1
  • Uniprot No.：
    Q8VD46
  • 别名：
    Asz1; GaszAnkyrin repeat; SAM and basic leucine zipper domain-containing protein 1; Germ cell-specific ankyrin; SAM and basic leucine zipper domain-containing protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-475
  • 氨基酸序列
    MAAGTLRGLA VAGGGESSDS EDDGWDIGYL DRSSQKLKRS LPVEEKNETF KKALTTGDIS LVKELLDSGI NVDSSFRYGW TPLMYAASVA NAELVRFLLD RGANASFDKD KLTILISACS ARGSEEQVLK CVELLLSRNA DPNTACRRLM TPIMYAARDG HTQVVALLVA HGAEVNAQDE NGYTALTWAA RQGHKNVILK LLELGANKML QTKDGRTPSE IAKRNKHLEI FNFLSLTLNP LEGKLQQLTK EETICKLLAT DSDKEKDHIF SPYTAFGDLE IFLHGLGLEH MTDSLKEKDI TLRHLLTMKK DELTKNGIAS KDQQKILAAL KELEVEEINF GKLPEVTKLE ISGDEFLNFL LKLNKQCGHL ITAVQNIITE LPVNSHKIVL EWASPRNFTS VCEELVSNVE DLNEEVCRLK ELIQKMQNER ENDPTHIPLV EEVSTWKTRI LKRSAVTVCG FGLLLFIGKL TLQRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
  • 基因功能参考文献：
    1. GASZ interacts with itself at the outer membrane of mitochondria and promotes mitofusion in a mitofusin/MFN-dependent manner. GASZ contains a functional mitochondrial targeting signal . PMID: 26711429
    2. Data reveal a potential role of GASZ during embryonic germ cell development and provide a powerful in vitro system for dissecting the molecular pathways in early germ cell formation during embryogenesis. PMID: 23816659
    3. GASZ is essential for meiosis and suppression of retrotransposon expression in the male germ cells. PMID: 19730684
  • 亚细胞定位：
    Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs.
  • 组织特异性：
    Expressed exclusively in testis and ovary with higher levels in testis.
  • 数据库链接：

    KEGG: mmu:74068

    STRING: 10090.ENSMUSP00000010940

    UniGene: Mm.73091

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