Recombinant Mouse Androgen receptor (Ar), partial

1. Here, the authors show that ERG, through its physical interaction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in the prostate glands of ERG transgenic mice. PMID: 28439080
2. CSN6 and Rab34 are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis. PMID: 29991022
3. Results provide evidence that androgen receptor is expressed from prenatal stages in mouse heart, supporting the proposition that androgens could be involved in mammalian heart development. PMID: 28806941
4. Androgens act via non-neural AR to mediate olfactory preference and neural responses to olfactory stimuli, and further, AR in non-neural tissues can promote androphilic odor preferences in male mice. PMID: 27191855
5. The role of ERbeta in opposing AR signaling, proliferation, and inflammation suggests that ERbeta-selective agonists may be used to prevent progression of prostate cancer, prevent fibrosis and development of benign prostatic hyperplasia, and treat prostatitis. PMID: 28439009
6. androgen receptor has a central role in the spontaneous regeneration of myelin PMID: 27930320
7. Data (including data from studies using transgenic/knockout mice) suggest that AR in insulin-secreting cells is involved in insulin secretion and inflammation; AR-deficient insulin-secreting cells exhibit altered expression of genes involved in inflammation and insulin secretion demonstrating importance of androgen action in functions of insulin-secreting cells. PMID: 28343791
8. Cyclic mechanical stretch modulated the proliferation of C2C12 cells, which may be attributed to the alterations of AR via IGF-1-PI3K/Akt and IGF-1-MAPK (p38, ERK1/2) pathways in C2C12 cells. PMID: 28454723
9. We show AR expressed in cancer-associated fibroblasts (CAFs) contributes to the tumor-promoting abilities that CAFs exert on epithelial prostate cancer cells. Further, we found that decreased AR expression in CAFs is also associated with an increase in stem cell marker gene expression in prostate cancer epithelial cells. PMID: 28264911
10. in clear cell renal cell carcinoma, enhances lung and liver metastases, while suppressing lymphatic metastasis PMID: 29030639
11. The results indicate that AR expression may be the gatekeeper of postoperative hepatocellular carcinoma recurrence PMID: 27340775
12. Glandular epithelial AR inactivation (with persistent stromal AR action) enhanced PTEN deletion-induced uterine pathology possibly by downregulating progesterone receptor expression in the uterus. PMID: 26984887
13. CDK2 phosphorylates polyQ-AR specifically at Ser(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy. PMID: 28003546
14. experimental manipulation of the prenatal androgen level, by blocking the androgen receptor with flutamide or activating the androgen receptor with dihydrotestosterone (DHT), leads to changes in the length of the fingers of all paws in males and females. PMID: 29176856
15. Silencing of androgen receptor rescues the muscular spinal atrophy transgenic mice. PMID: 27681426
16. Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. PMID: 27305909
17. Data provide evidence for a role of androgens via the AR in neurons to positively regulate fast-twitch hind-limb muscle mass and physical activity in male mice. PMID: 28977603
18. AR binds Sox2OT response elements in embryonic brain. PMID: 28704421
19. Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice PMID: 28493878
20. Disrupting luminal cell AR signaling in mouse models promotes cytokine production cell-autonomously, impairs epithelial barrier function, and induces immune cell infiltration. PMID: 27594448
21. Bisphenol A inhibits Sertoli cell proliferation by interfering with androgen receptor signaling pathway. PMID: 28645579
22. This study identifies AR as a novel receptor that enhances beta cell function. PMID: 27133133
23. Findings reveal for the first time that excessive Sertoli cell AR activity in mature testes can reach a level that disturbs Sertoli/germ cell homeostasis, impacts focal Leydig cell function, reduces sperm output, and disrupts male fertility. PMID: 27354237
24. Findings indicate that targeting androgen receptor (AR) with ASC-J9 in experimental autoimmune myocarditis (EAM) resulted in an attenuation in the severity of disease and cardiac injury. PMID: 28246012
25. The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate. PMID: 27137100
26. Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors. PMID: 27760825
27. Therefore, BA321 is a novel selective androgen receptor modulator (SARM) that may offer a new therapy option for osteoporosis in the male. PMID: 27402268
28. These findings suggested that androgen-AR suppressed obesity-induced chronic inflammation in adipose tissue. PMID: 27392713
29. We show that Foxp1 and the androgen receptor are co-expressed in striatal medium spiny neurons and that brain-specific androgen receptor KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 expression and ultrasonic vocalizations PMID: 28204507
30. Androgen-dependence of castration resistant prostate cancer (CRPC) is shown by forced AR overexpression or in isolation from the cellular secretory complement. Well established in vivo generated CRPC model cells did not need androgen when the cellular secretory milieu was restored. PMID: 27179779
31. Pharmacologic and genetic androgen receptor blockade causes attenuation of abdominal aortic aneurysm formation. PMID: 26817611
32. The results of the present study indicate that Aard is a target of AR action in mouse Sertoli cells and suggest a novel finding by which the loss of AR function in Sertoli cells blocks spermatogenesis and results in male infertility. PMID: 27959439
33. Seminal vesicles were evaluated by morphological and immunohistochemical parameters; androgenic receptor (AR), Insulin-like growth factor 1 (IGFR-1) and metalloproteinase 9 (MMP-9). Intense AR reactivity was seen in both stroma and epithelial regions in the TRAMP 22 group. Intense IGFR-1 and MMP-9 stromal immunolabeling was identified in both TRAMP groups PMID: 27036326
34. Data indicate that nuclear receptor subfamily 0 group B member 1 (Nr0b1) interacted with androgen receptor (AR) in Sertoli cells (SCs). PMID: 27431683
35. These results suggest that AR is an important regulator of myometrial growth in vivo during pregnancy and in leiomyoma. PMID: 26342051
36. results are the first to demonstrate that decidualization and progesterone significantly inhibited the AR protein expression in vivo, whereas estrogen increased AR protein levels in the stromal cells of mouse uteri. PMID: 26226925
37. these results demonstrate that Srsf4 is a direct downstream target of the androgen receptor in mouse Sertoli cells. PMID: 26308373
38. PRMT6, which was down-regulated by androgen receptors and influenced cell migration and apoptosis of germ cells, could play a potentially important role in spermatogenesis. PMID: 26690413
39. findings will enable us to begin understanding the important roles of AR and Cx43 actions in the regulation of follicular development PMID: 26206424
40. This increase in ER:AR ration as result of caloric restriction may lead to higher sensitivity to estrogens and upon return to normal diet may increase ovulation. PMID: 26264910
41. Data show that the timing of androgen receptor (AR) disruption determines the class of congenital penile anomaly. PMID: 26598695
42. synthetic antisense oligonucleotides inhibit RNA levels of mutant AR in the central nervous system and offer therapeutic effects in a spinal and bulbar muscular atrophy mouse model that harbors a mutant AR gene PMID: 26231218
43. Neural androgen nreceptor is critical for the processing of temporal information for visual objects, possibly through the modulation of glutamatergic transmission in the hippocampal CA1 area. PMID: 26849367
44. Results suggest novel roles for nonneural AR in sexual differentiation of mice, and indicate that excess AR can lead to a paradoxical reduction of male-typical behavior. PMID: 26636184
45. AR signaling regulates Mafb expression through the Mafb 3'UTR. PMID: 26636186
46. Data support the presence of new AR variants that may serve as important contributors during progression to castration resistant prostate cancer. PMID: 26196517
47. The effects of androgens on the cortical compartment result from AR signaling in osteoprogenitors or cells of the osteoclast lineage; or via estrogen receptor alpha (ERalpha) signaling in either or both of these two cell types. PMID: 25704845
48. the AR does not seem to suppress bone resorption through direct actions in osteoclasts. bone marrow stromal cells may however represent an alternative AR target in the bone marrow milieu. PMID: 25958043
49. This study provides further significant insight into the mechanism of androgen action via the AR in osteoblasts, demonstrating that it is dependent on the stage of osteoblast maturation. PMID: 25407961
50. AR signalling is dispensable in the male mouse pituitary for testosterone-dependent regulation of LH secretion PMID: 25799562

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KEGG: mmu:11835

STRING: 10090.ENSMUSP00000052648

UniGene: Mm.39005