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  4. Recombinant Mouse Alpha-globin transcription factor CP2 (Tfcp2)

Recombinant Mouse Alpha-globin transcription factor CP2 (Tfcp2)

  • 中文名称：
    小鼠Tfcp2重组蛋白
  • 货号：
    CSB-YP866828MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tfcp2重组蛋白
  • 货号：
    CSB-EP866828MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tfcp2重组蛋白
  • 货号：
    CSB-EP866828MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tfcp2重组蛋白
  • 货号：
    CSB-BP866828MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tfcp2重组蛋白
  • 货号：
    CSB-MP866828MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tfcp2
  • Uniprot No.：
    Q9ERA0
  • 别名：
    Tfcp2; Tcfcp2; Alpha-globin transcription factor CP2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-502
  • 氨基酸序列
    MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPPDN ENEILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML DNRKLGELPE LNGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGV IDPRANPTQL NTVEFLWDPS KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENG NGEYTEHLHS ASCQIKVFKP KGADRKQKID REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT NFSGADLLKL TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ LREQQPQPQP QPQKQEDGDS NGTFFVYHAI YLEELTAVEL TEKIAQLFSI SPHQISQIYK QGPTGIHVVI SDEMVQNFQE EACFILDTME AETSDSYHVI LK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1. Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.
  • 基因功能参考文献：
    1. The transcription factor CP2 upregulated miR-144 expression, which partially contributed to the suppression of COX-2 in mGCs. PMID: 28182010
    2. that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis PMID: 27612612
    3. Small molecule inhibitors of Late SV40 Factor abrogate hepatocellular carcinoma by inducing mitotic arrest and apoptosis. PMID: 26313006
    4. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma PMID: 22396589
    5. the binding of Pin1 at the Thr-329-Pro-330 motif in LSF permits isomerization by Pin1 of the peptide bonds at the nearby phosphorylated SP motifs (Ser-291 and Ser-309) to the trans configuration, thereby facilitating their dephosphorylation. PMID: 20682773
    6. CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin expression via up-regulating its transcription. PMID: 20796026
    7. CP2 is a major factor in the regulation of globin expression in human and mouse erythroid cells, and CP2 binding to the globin gene promoter is essential for the enhanced transcription of globin genes in erythroid differentiation. PMID: 12661759
    8. CP2 plays important role during bone development by activating BMP4 transcription PMID: 15232220
    9. A novel murine splice isoform of CP2, CP2b, which is identical to CP2a except that it has an additional 36 amino acids encoded by an extra exon was identified and characterized. PMID: 15988015
    10. findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta PMID: 16645641
    11. Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1). PMID: 19237534
    12. These data suggest that CP2b potentiate erythroid cell-specific alpha-globin expression by recruiting CP2c into the nucleus. PMID: 19338758

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Grh/CP2 family, CP2 subfamily
  • 数据库链接：

    KEGG: mmu:21422

    STRING: 10090.ENSMUSP00000009877

    UniGene: Mm.219040

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