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  4. Recombinant Mouse Alpha-crystallin A chain (Cryaa)

Recombinant Mouse Alpha-crystallin A chain (Cryaa)

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  • 中文名称：
    Recombinant Mouse Alpha-crystallin A chain (Cryaa)
  • 货号：
    CSB-EP006007MO
  • 规格：
    ￥1536
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Cryaa
  • Uniprot No.：
    P24622
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    29.4 kDa
  • 表达区域：
    1-196aa
  • 氨基酸序列
    MDVTIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISELMTHMWFVMHQPHAGNPKNNPVKVRSDRDKFVIFLDVKHFSPEDLTVKVLEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSERAIPVSREEKPSSAPSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • Datasheet & COA：
    Please contact us to get it.

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Cryaa Proteins

靶点详情

  • 功能：
    Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
  • 基因功能参考文献：
    1. findings offer additional insight into the early transcriptional changes caused by Cryaa and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo PMID: 29338044
    2. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf. PMID: 26719333
    3. Knockout of alphaA-crystallin inhibited pathologic neovascularization through the VEGF and VEGFR2 signaling pathways both in vitro and in vivo. PMID: 25574047
    4. the expression of alphaAN101D transgene results in disruption of lens morphogenesis, which is characterized by defective LEC proliferation, elongation, and lens fiber cell denucleation. PMID: 25146988
    5. p53 can regulate lens differentiation by controlling expression of the differentiation genes coding for the lens crystallins. PMID: 23745585
    6. Alpha A crystallin is a moonlighting protein that functions as a heat shock protein as well as a lens crystalline. PMID: 9695791
    7. alphaA-crystallin may protect against geographic atrophy. PMID: 22916220
    8. The expression patterns of lens crystallins were time- and strain-dependent but different from that of corneal crystallins in mouse corneal neovascularization models. PMID: 22465406
    9. alphaA and alphaB regulate caspase-3 and Bax in vitro and in vivo to regulate lens differentiation. PMID: 22280356
    10. Despite being overexpressed, the molecular properties of alpha-crystallins are disrupted by diabetes and contribute to the loss of neuroprotective function. PMID: 21467180
    11. these findings show that mutation of alphaA-crystallin induces activation of the UPR during cataract formation. PMID: 20833134
    12. Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability. PMID: 20085807
    13. Methionine oxidation of alpha-crystallin in combination with loss of MsrA repair causes loss of alpha-crystallin chaperone function. PMID: 19733220
    14. alphaA expression in vivo protects against cell death during mitosis in the lens epithelium PMID: 12584250
    15. mouse lens epithelial cell progression through the cell cycle is significantly affected by expression of alphaA and alphaB-crystallin PMID: 15543941
    16. tissue-specific expression of alphaA-crystallin is regulated by recruitment of Pax6 and c-Maf PMID: 16023139
    17. Alpha-crystallin plays a role in suppressing caspase activity, resulting in retention of lens fiber cell integrity following degradation of mitochondria and other organelles during the apoptosis-like pathway of lens cell terminal differentiation. PMID: 16439475
    18. The role of Cryab AND Cryaa in microtubule assembly is reported. PMID: 16675842
    19. Data suggest that moderate level of alphaA-crystallin gene expression in lens epithelial cells does not require the presence of CBP and p300 in the promoter. PMID: 17467007
    20. alphaA-crystallin regulates epithelial sodium channel expression PMID: 17664274
    21. Tau expression increases in the alpha-crystallin knockout lenses, suggesting that alphaA- and alphaB-crystallins are potentially important regulators of tau expression in lens. PMID: 17893660
    22. A modified genomic fragment of 15-kilobase Cryaa/enhanced green fluorescent protein (EGFP) is sufficient to direct the earliest onset of alphaA-crystallin/EGFP expression in the lens pit. PMID: 18803847
    23. Decreased gene expression of Cryaa and Cryab in the lens is associated with the development of cataract in OXYS rats. PMID: 19120020
    24. expression of R49C CRYAA mutant protein in the presence of the neor gene causes posterior cataracts with posterior migration of epithelial cell nuclei, and demonstrates that the mutant protein affects the integrity of lens fiber cells in the deep cortex. PMID: 19619312

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Small heat shock protein (HSP20) family
  • 数据库链接：

    KEGG: mmu:12954

    STRING: 10090.ENSMUSP00000019192

    UniGene: Mm.1228

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