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  4. Recombinant Mouse Alpha-actinin-3 (Actn3), partial

Recombinant Mouse Alpha-actinin-3 (Actn3), partial

  • 中文名称：
    Recombinant Mouse Alpha-actinin-3(Actn3) ,partial
  • 货号：
    CSB-YP001243MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-actinin-3(Actn3) ,partial
  • 货号：
    CSB-EP001243MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-actinin-3(Actn3) ,partial
  • 货号：
    CSB-EP001243MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-actinin-3(Actn3) ,partial
  • 货号：
    CSB-BP001243MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-actinin-3(Actn3) ,partial
  • 货号：
    CSB-MP001243MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Actn3
  • Uniprot No.：
    O88990
  • 别名：
    Actn3Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
  • 基因功能参考文献：
    1. ACTN3 gene dosage in muscle performance was investigated. PMID: 29706347
    2. ACTN3 is a genetic modifier of Duchenne muscular dystrophy. PMID: 28139640
    3. Actn3 knockout 129X1/SvJ mice gained less weight compared to wild type PMID: 28293018
    4. Actn3 controls sarcomeric composition and muscle function in a dose-dependent fashion. PMID: 26681802
    5. New insights that have been made in understanding the molecular mechanisms that underlie the consequences of alpha-actinin-3 deficiency.[review] PMID: 26802899
    6. Absence of alpha-actinin-3 resulted in reduced atrophic response and altered adaptation to disuse, as measured by a change in myosin heavy chain isoform. PMID: 24234654
    7. ACTN3 likely contributes to the regulation of bone mass through alterations in bone turnover. PMID: 21784188
    8. Data demonstrated that the Z-disk proteins, ZASP, titin and vinculin preferentially bind to alpha-actinin-2. Thus, the loss of alpha-actinin-3 changes the overall protein composition of fast fiber Z-disks and alters their elastic properties. PMID: 21536590
    9. Actn3 knockout mice showed differences in intrinsic exercise performance, fast muscle force generation and male muscle mass. PMID: 21112313
    10. alpha-actinin-3 may play a role in the development of fast-twitch, glycolytic properties in a muscle fiber, and in its absence slower twitch, more oxidative properties may develop. PMID: 20886650
    11. alpha-Actinin-3 deficiency reduces the activity of glycogen phosphorylase and results in a fundamental shift toward more oxidative pathways of energy utilization--REVIEW PMID: 20699471
    12. alpha-actinin-3 expression in a knockout mouse model results in a shift in muscle metabolism toward the more efficient aerobic pathway and an increase in intrinsic endurance performance PMID: 17828264
    13. Study reports that muscle from Actn3 knockout mice displays reduced force generation, consistent with results from human association studies. PMID: 18178581
    14. the shift towards more efficient aerobic muscle metabolism associated with alpha-actinin-3 deficiency also underlies the adaptive benefit of the 577X allele PMID: 18637739
    15. It was concluded that alpha-actinin-3 deficiency results in fast-twitch, glycolytic fibers developing slower-twitch, more oxidative properties. PMID: 18650267

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  • 蛋白家族：
    Alpha-actinin family
  • 数据库链接：

    KEGG: mmu:11474

    STRING: 10090.ENSMUSP00000006626

    UniGene: Mm.5316

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