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  4. Recombinant Mouse Alpha-2-macroglobulin-P (A2mp), partial

Recombinant Mouse Alpha-2-macroglobulin-P (A2mp), partial

  • 中文名称：
    Recombinant Mouse Alpha-2-macroglobulin-P(A2mp) ,partial
  • 货号：
    CSB-YP740120MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-macroglobulin-P(A2mp) ,partial
  • 货号：
    CSB-EP740120MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-macroglobulin-P(A2mp) ,partial
  • 货号：
    CSB-EP740120MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-macroglobulin-P(A2mp) ,partial
  • 货号：
    CSB-BP740120MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-2-macroglobulin-P(A2mp) ,partial
  • 货号：
    CSB-MP740120MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    A2m
  • Uniprot No.：
    Q6GQT1
  • 别名：
    A2m; A2mpAlpha-2-macroglobulin-P; Alpha-2-macroglobulin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
  • 基因功能参考文献：
    1. To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice PMID: 27031383
    2. Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase. PMID: 21320498
    3. MMP9 production promoted by the alpha(2)M*/LRP1 interaction required the activation of both MAPK-ERK1/2 and NF-kappaB signaling pathways. PMID: 20568116
    4. Alpha2 macroglobulin requires cyclic amp and signal transduction for cell growth PMID: 12114513
    5. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. PMID: 12183561
    6. the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents PMID: 15355875
    7. Data describe the role of the PI3-kinase/PDK/Akt/p70s6k signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB in these events. PMID: 15389876
    8. review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy. PMID: 16297527
    9. the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind PMID: 16407218
    10. PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit PMID: 16641085
    11. IL-11 signals through the Jak2/Stat3 pathway in decidual cells to stimulate the expression of alpha(2)-MG, a protease inhibitor essential for normal placentation in pregnancy. PMID: 16959875
    12. Prion protein paralog doppel protein interacts with alpha-2-macroglobulin PMID: 19536284

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 组织特异性：
    Expressed in uterus, mesometrial lymphoid aggregate and mammary tissue during pregnancy. Expressed in ovary, testis and kidney. Low level expression in heart. Not expressed in liver.
  • 数据库链接：

    KEGG: mmu:232345

    STRING: 10090.ENSMUSP00000032203

    UniGene: Mm.30151

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