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  4. Recombinant Mouse Aldehyde dehydrogenase, dimeric NADP-preferring (Aldh3a1)

Recombinant Mouse Aldehyde dehydrogenase, dimeric NADP-preferring (Aldh3a1)

  • 中文名称：
    Recombinant Mouse Aldehyde dehydrogenase, dimeric NADP-preferring(Aldh3a1)
  • 货号：
    CSB-EP001572MO
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Aldh3a1
  • Uniprot No.：
    P47739
  • 别名：
    Aldh3a1; Ahd-4; Ahd4; Aldh3; Aldh4; Aldehyde dehydrogenase; dimeric NADP-preferring; EC 1.2.1.5; Aldehyde dehydrogenase 4; Aldehyde dehydrogenase family 3 member A1; Dioxin-inducible aldehyde dehydrogenase 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    57.8 kDa
  • 表达区域：
    2-453aa
  • 氨基酸序列
    SNISSIVNRARDAFNSGKTRPLQFRVEQLEALQRMINENLKGISKALASNLRKNEWTSYYEEVAHVLDEIDFTIKGLSDWAEDEPVAKTRQTQEDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAIAAGNAVVLKPSEVSDHMADLLSTLIPQYMDKDLYPVIKGGVPETTELLKEKFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNEIVEKLKKSLKDFYGEDAKQSHDYGRIINDRHFQRVINLIDSKKVAHGGTWDQPSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLDEAIKFINQREKPLALYVFSNNDKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVRSLRNEEANKARYPPSPAKMPRH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    13-23 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Aldh3a1 Proteins

靶点详情

  • 功能：
    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
  • 基因功能参考文献：
    1. It is responsible for systemic alcohol metabolism. PMID: 29663519
    2. ALDH3A1 activation by d-limonene significantly reduced aldehyde accumulation in SSPCs. PMID: 29794221
    3. The corneal phenotype of Aldh3a1 showed no differences were observed in lipid profiles from knockout relative to wild type mice; however, changes in protein profiles of acyl-CoA binding protein (m/z 9966) and histone H4.4 (m/z 11308) were found to be increased in the corneal epithelial layer of knockout mice. PMID: 28038895
    4. ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms PMID: 26751691
    5. ADH3 protects liver from steatosis by supporting normal lipid metabolism and prevents progression of steatosis into steatohepatitis by maintaining the cellular glutathione level. PMID: 25777368
    6. focused on ALDH3A1, which is enriched in the upper aerodigestive track, and identified Alda-89 as a small molecule that enables ALDH3A1 to metabolize acetaldehyde PMID: 25713355
    7. Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status. PMID: 22683567
    8. ALDH activity is critical to metabolize acetaldehyde and prevent its accumulation to toxic levels that disrupt not only granulosa cell and theca cell functions but also proper oocyte development PMID: 22285649
    9. ALDH3A1 can compensate for ALDH1A1 in bone marrow & is important in B-cell development. Mice deficient in ALDH3A1 have a block in B-cell development as well as abnormalities in cell cycling, intracellular signaling, and gene expression. PMID: 22198153
    10. corneal ALDH3A1 and lens ALDH1A1 protect the eye against cataract formation via nonenzymatic (light filtering) and enzymatic (detoxification) functions. PMID: 17567582
    11. The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, while alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. PMID: 17629074
    12. Pax6, Oct1, and p300 activate gene expression of the corneal crystallin Aldh3a1 in the mouse. PMID: 18436815

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 组织特异性：
    Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder.
  • 数据库链接：

    KEGG: mmu:11670

    STRING: 10090.ENSMUSP00000019246

    UniGene: Mm.4257

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