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  4. Recombinant Mouse Adenylate kinase isoenzyme 1 (Ak1)

Recombinant Mouse Adenylate kinase isoenzyme 1 (Ak1)

  • 中文名称：
    Recombinant Mouse Adenylate kinase isoenzyme 1(Ak1)
  • 货号：
    CSB-YP870812MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate kinase isoenzyme 1(Ak1)
  • 货号：
    CSB-EP870812MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate kinase isoenzyme 1(Ak1)
  • 货号：
    CSB-EP870812MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate kinase isoenzyme 1(Ak1)
  • 货号：
    CSB-BP870812MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate kinase isoenzyme 1(Ak1)
  • 货号：
    CSB-MP870812MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ak1
  • Uniprot No.：
    Q9R0Y5
  • 别名：
    Ak1; Adenylate kinase isoenzyme 1; AK 1; EC 2.7.4.3; EC 2.7.4.6; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-194
  • 氨基酸序列
    MEEKLKKAKI IFVVGGPGSG KGTQCEKIVQ KYGYTHLSTG DLLRAEVSSG SERGKKLSAI MEKGELVPLD TVLDMLRDAM LAKVDSSNGF LIDGYPREVK QGEEFEQKIG QPTLLLYVDA GAETMTQRLL KRGETSGRVD DNEETIKKRL ETYYNATEPV ISFYDKRGIV RKVNAEGTVD TVFSEVCTYL DSLK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also possesses broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. May provide a mechanism to buffer the adenylate energy charge for sperm motility.
  • 基因功能参考文献：
    1. In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme. PMID: 24740601
    2. CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation. PMID: 23447692
    3. identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides PMID: 22637533
    4. AK1 is not involved in thiamine triphosphate synthesis in vivo PMID: 12379473
    5. Deficiency of this enzyme induces molecular and structural adaptations to support muscle energy metabolism. PMID: 12562761
    6. one of the consequences of M-CK and AK1 deficiency is hampered phosphoryl delivery to the actomyosin ATPase, resulting in a loss of contractile performance. PMID: 12730234
    7. Skeletal muscle of mdx mice has reduced expression and enzymatic activity of adenylate kinase 1, but increased enzymatic activity of creatine kinase PMID: 14625851
    8. The purpose of this study was to determine whether adenylate kinase 1 deficiency would result in sufficient ADP accumulation to be visible using (31)P-NMRS during the high energy demands of frequent in situ tetanic contractions. PMID: 15689408
    9. AK1 in the flagellar accessory structures provides a mechanism to buffer the adenylate energy charge for sperm motility PMID: 16790685
    10. Defective metabolic signaling in Ak1 gene knock-out hearts compromises post-ischemic coronary reflow. PMID: 17704060
    11. Adenylate kinase-1 knockout mice have a normal capacity for contraction-mediated glucose uptake. PMID: 17973952
    12. Creatine kinase (CK) and adenylate kinase (AK) are especially important in facilitating energy metabolism during very high energy demands. PMID: 19156695

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Adenylate kinase family, AK1 subfamily
  • 数据库链接：

    KEGG: mmu:11636

    STRING: 10090.ENSMUSP00000068479

    UniGene: Mm.29189

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