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  4. Recombinant Mouse Abnormal spindle-like microcephaly-associated protein homolog (Aspm), partial

Recombinant Mouse Abnormal spindle-like microcephaly-associated protein homolog (Aspm), partial

  • 中文名称：
    Recombinant Mouse Abnormal spindle-like microcephaly-associated protein homolog(Aspm) ,partial
  • 货号：
    CSB-YP809304MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Abnormal spindle-like microcephaly-associated protein homolog(Aspm) ,partial
  • 货号：
    CSB-EP809304MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Abnormal spindle-like microcephaly-associated protein homolog(Aspm) ,partial
  • 货号：
    CSB-EP809304MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Abnormal spindle-like microcephaly-associated protein homolog(Aspm) ,partial
  • 货号：
    CSB-BP809304MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Abnormal spindle-like microcephaly-associated protein homolog(Aspm) ,partial
  • 货号：
    CSB-MP809304MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Aspm
  • Uniprot No.：
    Q8CJ27
  • 别名：
    Aspm; Calmbp1; Sha1Abnormal spindle-like microcephaly-associated protein homolog; Calmodulin-binding protein Sha1; Calmodulin-binding protein 1; Spindle and hydroxyurea checkpoint abnormal protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seem to depend on its association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis.
  • 基因功能参考文献：
    1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity. PMID: 27562601
    2. Aspm and Wdr62 interact genetically to control brain size, with mice lacking Wdr62, Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and increased ectopic basal progenitors, suggesting premature delamination from the ventricular zone. PMID: 27974163
    3. Interaction between ASPM and the Cdk2/Cyclin E complex regulated the Cyclin activity by modulating its ubiquitination and localization into the nucleus. PMID: 26581405
    4. Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor. PMID: 26450969
    5. Aspm is essential to the proliferation and differentiation of neural stem/progenitor cells. The Aspm gene loss model provided a novel pathogenetic insight into acquired microcephaly, which can be caused by in utero exposure teratogens. PMID: 24220505
    6. ASPM plays a critical role in meiotic spindle assembly and meiotic progression in mouse oocytes. PMID: 23152892
    7. AspM is expressed by proliferating cells of the adult mouse SVZ that can generate neuroblasts fated to become olfactory bulb neurons PMID: 21559369
    8. knockdown of Aspm results in decreased Wnt-mediated transcription PMID: 21937711
    9. truncated Aspm proteins cause a massive loss of germ cells, resulting in a severe reduction in testis and ovary size accompanied by reduced fertility PMID: 20823249
    10. tissue distribution of Calmbp1 in fetal and adult mice PMID: 12351193
    11. evolutionary selection of specific segments of the ASPM sequence strongly relates to differences in cerebral cortical size PMID: 15045028
    12. Aspm is crucial for maintaining a cleavage plane orientation that allows symmetric, proliferative divisions of neuroepithelial cells during brain develo PMID: 16798874
    13. NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway PMID: 18728014

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus.
  • 组织特异性：
    Expressed in fetal brain, peripheral nervous system, liver and spleen. In the adult, expressed exclusively in testis, ovary and spleen.
  • 数据库链接：

    KEGG: mmu:12316

    STRING: 10090.ENSMUSP00000059159

    UniGene: Mm.168523

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