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  4. Recombinant Mouse ATPase inhibitor, mitochondrial (Atpif1)

Recombinant Mouse ATPase inhibitor, mitochondrial (Atpif1)

  • 中文名称：
    Recombinant Mouse ATPase inhibitor, mitochondrial(Atpif1)
  • 货号：
    CSB-YP002429MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse ATPase inhibitor, mitochondrial(Atpif1)
  • 货号：
    CSB-EP002429MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse ATPase inhibitor, mitochondrial(Atpif1)
  • 货号：
    CSB-EP002429MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse ATPase inhibitor, mitochondrial(Atpif1)
  • 货号：
    CSB-BP002429MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse ATPase inhibitor, mitochondrial(Atpif1)
  • 货号：
    CSB-MP002429MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atpif1
  • Uniprot No.：
    O35143
  • 别名：
    ATP5IF1; Atpi; Atpif1; If1ATPase inhibitor; mitochondrial; ATP synthase F1 subunit epsilon; Inhibitor of F(1)F(o)-ATPase; IF(1); IF1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-106
  • 氨基酸序列
    VSDSS DSMDTGAGSI REAGGAFGKR EKAEEDRYFR EKTKEQLAAL RKHHEDEIDH HSKEIERLQK QIERHKKKIQ QLKNNH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
  • 基因功能参考文献：
    1. Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1). PMID: 26595676
    2. induces VEGF expression and promotes xenograft tumor-induced angiogenesis PMID: 25042864
    3. IF1 is not an essential protein for mice despite its ubiquitous presence in eukaryotes. PMID: 23889209
    4. methionine deprivation results in an antioxidant response that includes an increase in the levels of HSPA1A and DNAJB1 mRNA PMID: 23402912
    5. the identification of mitochondrial Atpif1 as a regulator of haem synthesis advances our understanding of the mechanisms regulating mitochondrial haem homeostasis and red blood cell development PMID: 23135403
    6. Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis. PMID: 20538613
    7. The study reveals that IEX-1 targets the mitochondrial F1Fo-ATPase Inhibitor (IF1) for degradation, resulting in acceleration of ATP hydrolysis, concomitant with reduction in ROS production. PMID: 19096392

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    ATPase inhibitor family
  • 数据库链接：

    KEGG: mmu:11983

    STRING: 10090.ENSMUSP00000064282

    UniGene: Mm.2171

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