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  4. Recombinant Mouse ATP-dependent RNA helicase SUPV3L1, mitochondrial (Supv3l1)

Recombinant Mouse ATP-dependent RNA helicase SUPV3L1, mitochondrial (Supv3l1)

  • 中文名称：
    小鼠Supv3l1重组蛋白
  • 货号：
    CSB-YP773939MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Supv3l1重组蛋白
  • 货号：
    CSB-EP773939MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Supv3l1重组蛋白
  • 货号：
    CSB-EP773939MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Supv3l1重组蛋白
  • 货号：
    CSB-BP773939MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Supv3l1重组蛋白
  • 货号：
    CSB-MP773939MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Supv3l1
  • Uniprot No.：
    Q80YD1
  • 别名：
    Supv3l1; Suv3l1; ATP-dependent RNA helicase SUPV3L1; mitochondrial; EC 3.6.4.13; Suppressor of var1 3-like protein 1; SUV3-like protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    41-779
  • 氨基酸序列
    GRVPCLAASS SASGGSKAPN TSLFVPLTVK PQGPSADGDV GAELTRPLDK NEVKKILDKF YKRQEIQKLS ADYGLDARLF HQAFISFRNY IMQSHSLDVD IHIVLNDICF SAAHVDDLFP FFLRHAKQIF PVLECKDDLR KISDLRIPPN WYPEARARQR KIIFHSGPTN SGKTYHAIQR YLSATSGVYC GPLKLLAHEI FEKSNAAGVP CDLVTGEERL TVEPEGKQAT HVSCTVEMCN VATPYEVAVI DEIQMIRDPA RGWAWTRALL GLCAEEVHLC GESAAINLVS ELLYTTGEEV EVQKYERLTP ISVLDHALES LDNLQPGDCI VCFSKNDIYS VSRQIEIRGL ESAVIYGSLP PGTKLAQARK FNDPNDPCKI LVATDAIGMG LNLSIRRIIF YSLIKPSINE KGEKELEPIT TSQALQIAGR AGRFSSHFKE GQVTTMHRDD LALLKDILNR PVDPIQAAGL HPTAEQIEMF AYHLPETTLS NLIDIFVDFA QVDGQYFVCN MDDFKFSAEL IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VHDVFDLYLW LSYRFIDMFP DSSLVRSLQK ELDAIIQEGV HNITKLIKIS ESRKLLNLES LPSGDQSRLS GASKSPARRT RGTKSAGNKA TEPLSPSDKE LPLASRLVQQ GLLTADMLRQ LQKEWLTQQP EHSREKVGTR RKKKDPDSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
  • 基因功能参考文献：
    1. Spatial and temporal aspects of Supv3L1 promoter activity. PMID: 19937380
    2. Mice homozygous for Supv3L1 mutation die in utero before midgestation. PMID: 17961633
    3. Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes. PMID: 19145458
  • 亚细胞定位：
    Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
  • 蛋白家族：
    Helicase family
  • 数据库链接：

    KEGG: mmu:338359

    STRING: 10090.ENSMUSP00000020273

    UniGene: Mm.235898

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