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  4. Recombinant Mouse ATP-dependent DNA helicase Q4 (Recql4), partial

Recombinant Mouse ATP-dependent DNA helicase Q4 (Recql4), partial

  • 中文名称：
    小鼠Recql4重组蛋白
  • 货号：
    CSB-YP755211MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Recql4重组蛋白
  • 货号：
    CSB-EP755211MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Recql4重组蛋白
  • 货号：
    CSB-EP755211MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Recql4重组蛋白
  • 货号：
    CSB-BP755211MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Recql4重组蛋白
  • 货号：
    CSB-MP755211MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Recql4
  • Uniprot No.：
    Q75NR7
  • 别名：
    Recql4; Recq4; ATP-dependent DNA helicase Q4; EC 3.6.4.12; DNA helicase; RecQ-like type 4; RecQ4; RecQ protein-like 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-dependent ATPase. May play a role in development of the palate and the limbs. May modulate chromosome segregation.
  • 基因功能参考文献：
    1. RECQL4 is essential for normal bone development. Animals with no Recql4 in bone cells did not develop osteosarcoma. PMID: 25859855
    2. findings show that RECQL4 is critical for skeletal development by modulating p53 activity in vivo. PMID: 25556649
    3. data indicate that RECQL4 participates in DNA replication rather than genome stability and identify RECQL4 as a regulator of hematopoiesis with a nonredundant role compared with other RecQ helicases PMID: 24960165
    4. dysfunction of RECQL4 increases DNA damage and triggers premature senescence in both human and mouse cells, which may contribute to Rothmund-Thomson syndrome features in mice. PMID: 24832598
    5. Elevated expression of RECQL4 accompanies progression of the Rothmund-Thomson Syndrome into osteosarcoma in humans and mice. PMID: 24924172
    6. Recql4-deficient mice show growth retardation and skin abnormalities. PMID: 12915449
    7. Recql4 functions as a regulatory protein during osteoprogenitor proliferation, a critical cellular event during skeleton development. PMID: 16600186
    8. we define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14; a novel member of the LRR gene family, on the opposite strand PMID: 19720120

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Helicase family, RecQ subfamily
  • 数据库链接：

    KEGG: mmu:79456

    STRING: 10090.ENSMUSP00000044363

    UniGene: Mm.18373

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