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  4. Recombinant Mouse ATP-binding cassette sub-family A member 7 (Abca7), partial

Recombinant Mouse ATP-binding cassette sub-family A member 7 (Abca7), partial

  • 中文名称：
    Recombinant Mouse ATP-binding cassette sub-family A member 7(Abca7) ,partial
  • 货号：
    CSB-YP845971MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse ATP-binding cassette sub-family A member 7(Abca7) ,partial
  • 货号：
    CSB-EP845971MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse ATP-binding cassette sub-family A member 7(Abca7) ,partial
  • 货号：
    CSB-EP845971MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse ATP-binding cassette sub-family A member 7(Abca7) ,partial
  • 货号：
    CSB-BP845971MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse ATP-binding cassette sub-family A member 7(Abca7) ,partial
  • 货号：
    CSB-MP845971MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abca7
  • Uniprot No.：
    Q91V24
  • 别名：
    Abca7ATP-binding cassette sub-family A member 7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing.
  • 基因功能参考文献：
    1. Study demonstrates that changes in surface CD1d expression and intracellular trafficking, as well as reduced CD1d localization to lipid rafts, are all caused by the absence of the ATP binding cassette transporter ABCA7. PMID: 28091533
    2. ABCA7 does not play a significant role in the regulation of cell proliferation or neurogenesis in the adult mouse. PMID: 26792809
    3. This study demonstrated that novel mechanism underlying how dysfunctions of ABCA7 contribute to the risk for alzheimer disease. PMID: 27030769
    4. ABCA7 has a role in Alzheimer amyloid processing PMID: 26260791
    5. Theresults of this study suggested that ABCA7 plays a role in the regulation of Abeta homeostasis in the brain and that this may be related to altered phagocyte function. PMID: 23467355
    6. Male knockout mice exhibited significantly impaired novel object recognition memory.Female knockout mice exhibited impaired spatial reference memory. PMID: 23029339
    7. ABCA7 may play a role in T cell proliferation and erythropoeisis in spleen PMID: 22403608
    8. concluded that statins enhance macrophage phagocytosis through the SREBP-ABCA7 pathway. PMID: 21762915
    9. Data suggest that extracellular helical apolipoproteins augment ABCA7-associated phagocytosis by stabilizing ABCA7, and show direct enhancement of the host defense system by HDL components. PMID: 20495215
    10. ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and has a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues PMID: 12917409
    11. genetic knockdown of ABCA7 in mouse peritoneal macrophages did not affect phospholipid or cholesterol efflux to apoA-I PMID: 15520449
    12. ABCA7 plays a novel role in lipid and fat metabolism PMID: 15550377
    13. Mouse spermatozoa in the seminiferous tubules and epididymis express ABCA1, ABCA7 and ABCG1. PMID: 18793613

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, ruffle membrane. Cell projection, phagocytic cup.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 组织特异性：
    Widely expressed with higher expression in brain, lung, adrenal gland, spleen and hematopoietic tissues (at protein level). In the brain, expressed in cortex, cerebellum, hippocampus, olfactory bulb, neurons, astrocytes and microglia (at protein level). A
  • 数据库链接：

    KEGG: mmu:27403

    STRING: 10090.ENSMUSP00000043090

    UniGene: Mm.103351

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