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  4. Recombinant Mouse A/G-specific adenine DNA glycosylase (Mutyh)

Recombinant Mouse A/G-specific adenine DNA glycosylase (Mutyh)

  • 中文名称：
    小鼠Mutyh重组蛋白
  • 货号：
    CSB-YP860410MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mutyh重组蛋白
  • 货号：
    CSB-EP860410MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mutyh重组蛋白
  • 货号：
    CSB-EP860410MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mutyh重组蛋白
  • 货号：
    CSB-BP860410MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mutyh重组蛋白
  • 货号：
    CSB-MP860410MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mutyh
  • Uniprot No.：
    Q99P21
  • 别名：
    Mutyh; Myh; Adenine DNA glycosylase; EC 3.2.2.31; MutY homolog; mMYH
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-515
  • 氨基酸序列
    MKKLQASVRS HKKQPANHKR RRTRALSSSQ AKPSSLDGLA KQKREELLQA SVSPYHLFSD VADVTAFRSN LLSWYDQEKR DLPWRNLAKE EANSDRRAYA VWVSEVMLQQ TQVATVIDYY TRWMQKWPKL QDLASASLEE VNQLWSGLGY YSRGRRLQEG ARKVVEELGG HMPRTAETLQ QLLPGVGRYT AGAIASIAFD QVTGVVDGNV LRVLCRVRAI GADPTSTLVS HHLWNLAQQL VDPARPGDFN QAAMELGATV CTPQRPLCSH CPVQSLCRAY QRVQRGQLSA LPGRPDIEEC ALNTRQCQLC LTSSSPWDPS MGVANFPRKA SRRPPREEYS ATCVVEQPGA IGGPLVLLVQ RPDSGLLAGL WEFPSVTLEP SEQHQHKALL QELQRWCGPL PAIRLQHLGE VIHIFSHIKL TYQVYSLALD QAPASTAPPG ARWLTWEEFC NAAVSTAMKK VFRMYEDHRQ GTRKGSKRSQ VCPPSSRKKP SLGQQVLDTF FQRHIPTDKP NSTTQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
  • 基因功能参考文献：
    1. results suggested that MYH, which interacts with TRADD, inhibits TNF-alpha necroptotic signaling. Therefore, MYH inactivation is essential for necroptosis via the downregulation of caspase-8. PMID: 28059467
    2. Ogg1 and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior. PMID: 26711335
    3. MUTYH loss is associated with an increase in inflammation associated colorectal cancer risk, which involves immunosuppression and altered inflammatory response. PMID: 26109431
    4. Results show that MYH is a vital DNA repair enzyme that protects cells from oxidative DNA damage and is critical for a proper cellular response to DNA damage. PMID: 24315136
    5. a 5-methylcytosine glycosylase activity for the murine DNA base excision repair enzyme Myh is described and shown that it is critically involved in remodeling the IL-2 Promoter for transcription. PMID: 24291244
    6. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1, Neil1, Mutyh and Xrcc1 in the brain of adult offspring. PMID: 23603834
    7. The action of MUTYH, which initiates excision repair of adenine opposite 8-oxoG, triggers neurodegeneration in mice. PMID: 23143307
    8. OGG1 and MYH appear to be dispensable for antimutator function in mitochondria. PMID: 22209780
    9. Mutyh plays a major role in maintaining intestinal integrity by affecting the inflammatory response. PMID: 20706593
    10. Aim of this study was to characterize the biological effects, in a mammalian cell background, of human MUTYH mutations identified in MUTYH-associated polyposis patients PMID: 19953527
    11. Replication-associated repair of adenine:8-oxoguanine mispairs by MYH PMID: 11864576
    12. a specific germ-line mutation (G382D) is identified in mutyH which may be responsible for the mutator phenotype PMID: 12917422
    13. MUTYHalpha and MUTYHbeta were detected in wild-type embryonic stem (ES) cells or thymocytes prepared from wild-type mice PMID: 14742662
    14. The C-terminal domain of MUTYH is necessary for its ability to prevent OGG1 or APEX1 from inappropriately processing its substrate. PMID: 15199168
    15. Because there is an increased incidence of lung and small intestine cancer in Myh(-/-)/Ogg1(-/-) mice, these findings support a causal role for unrepaired oxidized DNA bases in cancer development. PMID: 15231648
    16. MUTYH has a DNA glycosylase activity excising not only adenine opposite 8-oxoguanine (8-oxoG) but also 2-hydroxyadenine (2-OH-A) opposite guanine. PMID: 15681617
    17. MUTYH suppresses spontaneous tumorigenesis in mice, thus providing experimental evidence for the association between biallelic germ-line MUTYH mutations and a recessive form of human hereditary colorectal adenoma and carcinoma PMID: 17638869
    18. Required for normal cell-cycle progression and nuclear division, suggesting multiple roles of Myh in the maintenance of genome stability and tumor prevention. PMID: 18258604
    19. A large fraction of the cancer-prone phenotype of Msh2 deficient mice depends on Mutyh activity. PMID: 19435918

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  • 亚细胞定位：
    Nucleus. Mitochondrion.
  • 蛋白家族：
    Nth/MutY family
  • 组织特异性：
    Expressed in heart, lung, liver, intestine, brain and thymus.
  • 数据库链接：

    KEGG: mmu:70603

    STRING: 10090.ENSMUSP00000099760

    UniGene: Mm.180333

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